Form Formononetin
Description: <b>Formononetin</b> is an O-methylated isoflavone.<br>
Found in several plant sources, including:<br>
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Red Clover (Trifolium pratense):<br>
Astragalus membranaceus:<br>
Other Leguminous Plants:<br>
-Various plants in the legume family (Fabaceae) may also contain formononetin, although the levels and bioavailability can differ depending on the plant species and extraction methods.<br>
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Pathways:<br>
PI3K/Akt Pathway: formononetin may inhibit the phosphorylation of Akt<br>
(MAPK) Pathway: may modulate components of the MAPK pathway<br>
STAT3 Signaling Pathway: formononetin can downregulate STAT3 activity<br>
NF-κB Pathway: modulating NF-κB activation<br>
Apoptotic Pathways: via mitochondrial-dependent pathways, enhancing caspase activation <br>
Induce cell cycle arrest at different checkpoints (e.g., G1 or G2/M phases)<br>
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Formononetin, a naturally occurring isoflavone found in red clover, Astragalus membranaceus, and other leguminous plants, shows promise as an anticancer agent. Its ability to modulate key signaling pathways—including PI3K/Akt, MAPK, STAT3, NF-κB, and apoptotic and cell cycle regulatory mechanisms—suggests a multifaceted potential in cancer prevention and therapy.<br>