acet acetaminophen
Description: <b>Acetaminophen:</b> The most common name in the United States.<br>
Paracetamol: The name used in most of the world.<br>
APAP: A common abbreviation used in biochemical and pharmacological studies.<br>
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<b>Pathways:</b><br>
-Cytochrome P450 Metabolism: NAPQI (N-acetyl-p-benzoquinone imine)<br>
-Excess NAPQI depletes glutathione, a key antioxidant. The absence of sufficient glutathione leads to elevated oxidative stress.<br>
-NF-κB Activation:<br>
-Direct DNA Damage:<br>
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Excess results in increased oxidative stress, mitochondrial dysfunction, and ultimately hepatocellular damage (liver injury)<br>