Purp Purpurone
Description: <b>Purpurone</b> is a natural product. Many reports indicate that it belongs to a family of naphthoquinone derivatives.<br>
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Pathways:<br>
Induction of Apoptosis (Intrinsic/Mitochondrial Pathway):<br>
– affecting MMP, leading to the release of cytochrome c and activation of downstream caspases.<br>
Inhibition of NF-κB Signaling:<br>
Cell Cycle Arrest: (often at the G2/M phase).<br>
Induction of Oxidative Stress (ROS Generation):<br>
Anti-Angiogenic Effects: inhibiting angiogenesis<br>
ACLY inhibitor: IC50 = 7 uM <br>