tbResList Print — sericin sericin

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Product

sericin sericin
Description: <b>Sericin</b> is a silk protein primarily obtained from the silkworm Bombyx mori and has attracted interest for its various biological properties. Some studies have investigated the potential anticancer properties of sericin.<br>
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-Sericin exhibits antioxidant properties, which may help protect cells against oxidative stress. Oxidative stress is known to contribute to the development and progression of cancer, so antioxidants are often considered beneficial in preventive strategies.<br>
-Sericin’s anti-inflammatory effects might help reduce inflammation-related damage and potentially slow down processes that can lead to carcinogenesis.<br>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress(tgid=1)

ROS↓, 1,  

Cell Death(tgid=5)

Akt↓, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12)

FOXO1↑, 1,   mTOR↓, 1,   PI3K↓, 1,  

Migration(tgid=13)

TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21)

eff↑, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells

Functional Outcomes(tgid=23)

toxicity∅, 1,  
Total Targets: 1

Research papers

Year Title Authors PMID Link Flag
2024In vitro and in vivo anti-colorectal cancer effect of the newly synthesized sericin/propolis/fluorouracil nanoplatform through modulation of PI3K/AKT/mTOR pathwayShaimaa E DiabPMC10825195https://pmc.ncbi.nlm.nih.gov/articles/PMC10825195/0