DAP Dichloroacetophenone(2,2-)
Description: <b>2,2-Dichloroacetophenone (DAP)</b> is an acetophenone derivative characterized by the presence of two chlorine atoms on the aromatic ring, typically at the 2‑position relative to the carbonyl group. Its structure and properties differ significantly from compounds like dichloroacetate (DCA). <br>
-DAP may trigger the production of reactive oxygen species (ROS) in cells.<br>
-Increased ROS can lead to cellular damage, which may trigger apoptosis (programmed cell death) in cancer cells that are already under metabolic and oxidative stress.<br>
-Cytotoxic effects via DNA damage.<br>
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*** Importantly, 2,2-dichloroacetophenone (DAP) is a much more potent inhibitor of PDK1(Than DCA). It is effective at concentrations in the micromolar (μM) range.<br>