Nos Noscapine
Description: <b>Noscapine</b> is a natural product. It is an isoquinoline alkaloid derived from the opium poppy (Papaver somniferum), although unlike some opium alkaloids, it does not have narcotic effects.<br>
-Historically, it has been used as an antitussive (cough suppressant) due to its antitussive properties without causing the sedation associated with opiates.<br>
<br>
Pathways:<br>
-Mitochondrial stress, release of cytochrome c, and activation of caspases (such as caspase-3), leading to cellular apoptosis.<br>
-Inhibit angiogenesis<br>
-Interfere with the NF-κB signaling pathway<br>
<br>
-Noscapine can enhance the effects of traditional chemotherapeutics when used in combination. It may help overcome drug resistance by modulating cell cycle regulators and apoptosis-related proteins.<br>