LapC Lapachol
Description: <b>Lapachol</b> is a natural naphthoquinone originally derived from the heartwood of the lapacho tree (Tabebuia species).<br>
<br>
Pathways:<br><br>
Oxidative Stress and ROS Generation<br>
–Like many quinones, lapachol can undergo redox cycling that generates reactive oxygen species (ROS).<br>
-Oxidative damage to DNA, proteins, and lipids, thereby promoting cancer cell death.<br>
-cell cycle at specific checkpoints (commonly at G0/G1 or G2/M phases)<br>
-Inhibition of the NF‑κB signaling pathway<br>
–MAPK Pathways<br>
<br>
-ic50 cancer cells 10-50uM, normal cells higher (existence of a therapeutic window)<br>