tbResList Print — born borneol

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Product

born borneol
Description: <b>Borneol</b> is a bicyclic organic compound and a type of monoterpenoid that occurs naturally in various essential oils.<br>
-Recent studies have been exploring borneol’s ability to enhance drug delivery—especially across the blood-brain barrier.<br>
-Borneol is particularly known for its ability to act as a penetration enhancer. This quality can improve the absorption of various drugs, potentially increasing their efficacy when used in combination with other therapeutic agents.<br>
-Borneol is thought to temporarily open tight junctions between endothelial cells, enhancing drug penetration. It may also downregulate efflux transporters such as P-glycoprotein (P-gp), allowing higher intracellular concentrations of co-administered drugs.<br>
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Sources:<br>
-Cinnamomum camphora (camphor tree), its essential oil contains borneol along with camphor.<br>
-Dryobalanops aromatica,Often referred to as the camphor tree in Southeast Asia, its oleoresin is a well-known source of natural borneol. <br>
-Blumea balsamifera<br>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress

ROS↑, 1,  

Cell Death

Apoptosis↑, 1,  

Cell Cycle & Senescence

TumCCA↑, 1,  

Drug Metabolism & Resistance

BioAv↓, 1,   BioAv↑, 1,   eff↑, 1,   selectivity↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2023Natural borneol serves as an adjuvant agent to promote the cellular uptake of piperlongumine for improving its antiglioma efficacyMenglu Wang36493999https://pubmed.ncbi.nlm.nih.gov/36493999/0