Vem verapamil
Description: <b>Verapamil</b> belongs to the phenylalkylamine class of compounds and is a fully synthetic molecule originally developed for its potent calcium channel–blocking properties.<br>
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Pathways:<br>
-P-glycoprotein Inhibition (MDR1). -P-gp is overexpressed in many cancer cells<br>
-Inhibition of P-gp by verapamil can enhance the intracellular concentration of chemotherapeutic agents, potentially restoring drug sensitivity.<br>
-As a calcium channel blocker, verapamil inhibits L-type calcium channels.<br>