tbResList Print — SAHA Vorinostat

Filters: qv=305, qv2=%, rfv=%

Product

SAHA Vorinostat
Description: <b>Suberoylanilide hydroxamic acid (SAHA)</b> (Vorinostat) is a synthetic compound. It was designed and developed as a small-molecule inhibitor targeting HDAC enzymes.<br>
<br>
-Anticancer effects primarily through the inhibition of histone deacetylases (HDACs).<br>
-Reactivation of tumor suppressor genes.<br>
-Cell cycle arrest via upregulation of inhibitors like p21.<br>

Pathway results for Effect on Cancer / Diseased Cells

Cell Death ⓘ

Apoptosis↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1,   HDAC↓, 1,   TumCG↓, 1,  

Migration ⓘ

TXNIP↑, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2002The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxinLisa M ButlerPMC129332https://pmc.ncbi.nlm.nih.gov/articles/PMC129332/0