Description: <b>Ukrain</b> is often said to be based on extracts from the greater celandine plant (Chelidonium majus), which has been used in traditional medicine.<br>
-Although its active components are derived from a natural source, the final product is processed and standardized in a pharmaceutical setting. This means Ukrain is more accurately described as a semi-synthetic or phytochemical-based drug rather than a crude natural remedy.<br>
-Celandine sap is used to treat warts and skin cancer (98% alkaloids)<br>
-Chelidonine (80% of alkaloids) is most important<br>
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-Claimed to affect cancer cells and not normal cells<br>
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Pathways:<br>
-Ukrain may induce apoptosis, MMP depolarization, cyt-c release, caspase activation.<br>
-Ukrain might increase the production of reactive oxygen species in cancer cells.<br>
-Cell Cycle Arrest<br>
-p53 pathway<br>
-(MAPK) pathways<br>
-NF-κB) signaling<br>
-Inhibit angiogenesis<br>
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The researchers suggest there might be a probable relationship between liver injury and consumption of Chelidonium majus.<br>
<a href="https://www.ukrain.ua/" >https://www.ukrain.ua/ </a>
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<a href="https://www.researchgate.net/scientific-contributions/A-Liepins-40092131">
Dr. Andrejs Liepins</a><br>
Memorial University of Newfoundland<br>
Faculty of Medicine<br>
St John's Newfoundland<br>
Canada A1B 3V6<br>