tbResList Print — Wog Wogonin

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Product

Wog Wogonin
Description: <b>Wogonin</b> is a naturally occurring flavonoid typically isolated from Scutellaria baicalensis and has been the focus of cancer research due to its potential anticancer properties. <br>
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Pathways:<br>
-PI3K/Akt Pathway Inhibition<br>
-NF-κB Pathway Suppression<br>
-MAPK Pathway Modulation (ERK, JNK, and p38)<br>
-STAT3 Signaling Inhibition:<br>
-Reactive Oxygen Species (ROS) Generation<br>
-Decreases in HKII, PDK1, and LDHA expression<br>
-Suppression of lactate generation, and reduced glucose uptake<br>

Pathway results for Effect on Cancer / Diseased Cells

Mitochondria & Bioenergetics ⓘ

mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

ECAR↓, 1,   Glycolysis↓, 2,   HK2↓, 1,   lactateProd↓, 1,   LDH↓, 1,   LDHA↓, 1,   MCT4↓, 1,   PDK1↓, 1,  

Cell Death ⓘ

Akt↓, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↓, 1,  

Migration ⓘ

Ca+2↑, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 2,   NO↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   PGE2↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   eff↓, 1,  

Clinical Biomarkers ⓘ

LDH↓, 1,  
Total Targets: 22

Pathway results for Effect on Normal Cells

Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 1

Research papers

Year Title Authors PMID Link Flag
2022Natural compounds targeting glycolysis as promising therapeutics for gastric cancer: A reviewMaoyuan ZhaoPMC9684197https://pmc.ncbi.nlm.nih.gov/articles/PMC9684197/0
2021Flavonoids Targeting HIF-1: Implications on Cancer MetabolismMarek SamecPMC7794792https://pmc.ncbi.nlm.nih.gov/articles/PMC7794792/0
2011Anti-cancer natural products isolated from chinese medicinal herbsWen TanPMC3149025https://pmc.ncbi.nlm.nih.gov/articles/PMC3149025/?report=classic0