tbResList Print — lamb lambertianic acid

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Product

lamb lambertianic acid
Description: <b>Lambertianic acid</b> is a naturally occurring diterpenoid, derived from Pinus koraiensis<br>
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Pathways:<br>
-inhibit the STAT3 signaling<br>
-suppress NF-κB activation<br>
-PI3K/Akt pathway<br>
-inhibit PKM2<br>
-increase ROS<br>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

proCasp3↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

proPARP↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑GSK‐3β↓, 1,   p‑STAT3↓, 1,  

Migration(tgid=13) ⓘ

β-catenin/ZEB1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2023Anti-Warburg effect via generation of ROS and inhibition of PKM2/β-catenin mediates apoptosis of lambertianic acid in prostate cancer cellsPak JN—https://europepmc.org/article/MED/372354810