tbResList Print — Wor Worenine

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Product

Wor Worenine
Description: <b>Worenine</b> - Coptis Chinensis (Huanglian in Chinese), a famous traditional herbal medicine used for clearing heat and detoxification.<br>
Worenine is classified as a plant-derived alkaloid.<br>
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-Worenine may exert anti-inflammatory and antioxidant effects.<br>
-Production of lactic acid and the uptake and consumption of glucose is significantly inhibited.<br>
-The protein and mRNA levels of GLUT3, HK2, PFK-L, PKM2, and LDHA in HCT116 cells are reduced.<br>

Pathway results for Effect on Cancer / Diseased Cells

Core Metabolism/Glycolysis

GlucoseCon↓, 1,   HK2↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   PKM2↓, 1,  

Barriers & Transport

GLUT3↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2023Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of actionLu Zhanhttps://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1257450/full0