tbResList Print — TTT Tumor Treating Fields

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Product

TTT Tumor Treating Fields
Description: <b>Tumor Treating Fields (TTFields)</b> are a physical, noninvasive treatment modality that uses alternating electric fields in the intermediate frequency range (typically around 100–300 kHz) and low intensity to disrupt cancer cell division. Unlike conventional therapies that target specific molecular pathways with drugs, TTFields work by exerting physical forces on charged and polarizable cellular structures. Nevertheless, several downstream biological effects and pathways have been observed when tumor cells are exposed to TTFields.<br>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress ⓘ

OXPHOS↑, 1,  

Core Metabolism/Glycolysis ⓘ

Glycolysis↓, 1,   PKM2↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↝, 1,  

Functional Outcomes ⓘ

OS↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells

Migration ⓘ

TumCP↑, 1,  
Total Targets: 1

Research papers

Year Title Authors PMID Link Flag
2024Tumor treating induced fields: a new treatment option for patients with glioblastomaZehao Cai—https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1413236/full0
2023A review of tumor treating fields (TTFields): advancements in clinical applications and mechanistic insightsXing LiPMC10476910https://pmc.ncbi.nlm.nih.gov/articles/PMC10476910/0
2020Tumor treating fields (TTFields) impairs aberrant glycolysis in glioblastoma as evaluated by [18F]DASA-23, a non-invasive probe of pyruvate kinase M2 (PKM2) expressionChirag B PatelPMC7689378https://pmc.ncbi.nlm.nih.gov/articles/PMC7689378/0