tbResList Print — γ-Toc γ-Tocotrienol

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Product

γ-Toc γ-Tocotrienol
Description: <b>γ‐Tocotrienol</b> is one of the tocotrienol isomers in the vitamin E family.<br>
γ‐Tocotrienol is naturally found in certain plant oils.<br>
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– Notable sources include palm oil, rice bran oil, barley, and annatto.<br>
– Among these, annatto oil is often highlighted as a particularly rich source of tocotrienols (with γ‐tocotrienol being one of the major components).<br>
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• Relationship within the Vitamin E Family<br>
– Tocotrienols, including the γ isomer, are one of the two classes of vitamin E compounds (the other being tocopherols).<br>
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Pathways:<br>
-Inhibition of NF‑κB Signaling<br>
-downregulate the PI3K/Akt signaling cascade<br>
-inhibit STAT3 activation<br>
-Cell Cycle Arrest<br>
-Antioxidant and Anti‑Inflammatory Effects(reduce reactive oxygen species (ROS) levels)<br>
-may reduce angiogenic factors such as vascular endothelial growth factor (VEGF)<br>
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<a href="https://nowfoods.ca/product/gamma-e-complex-tocopherols-tocotrienols/">Gamma E Complex (Tocopherols/Tocotrienols) example source</a><br>
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Pathway results for Effect on Cancer / Diseased Cells

Mitochondria & Bioenergetics

ATP↓, 1,  

Core Metabolism/Glycolysis

cMyc↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   PFK↓, 1,   PKM2↓, 1,  

Cell Death

Akt↓, 1,  

Proliferation, Differentiation & Cell State

p‑mTOR↓, 1,   TumCG↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2015Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic GlycolysisParash Parajulihttps://www.jstage.jst.go.jp/article/bpb/38/9/38_b15-00306/_html0