tbResList Print — PA Pachymic acid

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Product

PA Pachymic acid
Description: <b>Pachymic acid</b> is a lanostane-type triterpenoid predominantly extracted from the sclerotium of the fungus Poria cocos (also known as Fu Ling in Traditional Chinese Medicine).<br>
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Pachymic acid (PA) is a triterpene found in Poria, and molecular docking revealed that PA has a much higher affinity for HK II than G6P (molecular docking scores of 8.18 and 5.31, respectively)<br>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress ⓘ

ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 2,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

GlucoseCon↓, 1,   HK2↓, 2,   lactateProd↓, 1,   PKM2↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2023The Promoting Role of HK II in Tumor Development and the Research Progress of Its InhibitorsKyoko Nakagawa-Goto—https://www.mdpi.com/1420-3049/29/1/750
2019Targeting Pyruvate Kinase M2 and Hexokinase II, Pachymic Acid Impairs Glucose Metabolism and Induces Mitochondrial ApoptosisGuopeng Miao—https://www.jstage.jst.go.jp/article/bpb/42/1/42_b18-00730/_article0