tbResList Print — Trip triptolide

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Product

Trip triptolide
Description: <b>Triptolide</b> is a diterpenoid triepoxide primarily isolated from the traditional Chinese medicinal plant Tripterygium wilfordii Hook F (commonly known as Thunder God Vine).<br>
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Pathways:<br>
-Activation of caspases (key executioners of apoptosis)<br>
-Disruption of mitochondrial membrane potential<br>
-Cell Cycle Arrest<br>
-Suppresses expression of c-myc and mitochondrial hexokinase II (HK-II) in cancer cells<br>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress(tgid=1) ⓘ

NRF2↓, 1,   ROS↑, 2,   xCT/SLC7A11↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,  

Cell Death(tgid=5) ⓘ

BAD↑, 1,   BAX↑, 1,   Casp3↑, 1,   GSDME-N↑, 1,   Pyro↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↓, 1,   eff↑, 2,   selectivity↑, 1,  
Total Targets: 20

Pathway results for Effect on Normal Cells

Redox & Oxidative Stress(tgid=1) ⓘ

ROS∅, 1,  
Total Targets: 1

Research papers

Year Title Authors PMID Link Flag
2021Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙJing CaiPMC8188724https://pmc.ncbi.nlm.nih.gov/articles/PMC8188724/0
2006Potential of traditional ayurvedic formulation, Triphala, as a novel anticancer drugT Sandhya15899544https://pubmed.ncbi.nlm.nih.gov/15899544/0