tbResList Print — TACE Transarterial Chemoembolization

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TACE Transarterial Chemoembolization
Description: <b>TACE</b>, which stands for Transarterial Chemoembolization—a treatment primarily used for certain types of cancer, most notably liver cancer (hepatocellular carcinoma).<br>
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TACE is a minimally invasive procedure that involves delivering chemotherapy directly into the artery that supplies blood to a tumor (most commonly in the liver) and then injecting substances to block (embolize) the artery. This dual action attacks the tumor by:<br>
-Concentrating chemotherapy at the site of the tumor.<br>
-Restricting the tumor’s blood supply, which helps to starve the cancer cells of oxygen and nutrients.<br>
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How It Works:<br>
-Catheter Insertion: A catheter is inserted through a small incision, usually in the groin, and navigated into the arterial system to reach the hepatic artery (if treating liver cancer).<br>
-Chemotherapy Delivery: A concentrated dose of chemotherapy is delivered directly into the blood vessels feeding the tumor.<br>
-Embolization: Embolic agents (such as gelatin sponge particles, microspheres, or other embolic materials) are then injected to block the artery, thereby limiting the tumor’s blood flow.<br>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress

ROS↑, 1,  

Proliferation, Differentiation & Cell State

TumCG↓, 1,  

Drug Metabolism & Resistance

Dose↝, 2,  

Functional Outcomes

Remission↑, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2015High-Dose Vitamin C Promotes Regression of Multiple Pulmonary Metastases Originating from Hepatocellular CarcinomaMin-Seok SeoPMC4541681https://pmc.ncbi.nlm.nih.gov/articles/PMC4541681/0