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metroC metronomic chemo
Description: <b>Metronomic chemotherapy</b> refers to the therapeutic strategy of administering chemotherapeutic drugs at relatively low, minimally toxic doses on a frequent or continuous schedule without extended rest periods. This dosing regimen contrasts with traditional maximum tolerated dose (MTD) chemotherapy, which involves high doses given intermittently with breaks to allow patient recovery.<br>
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-The drugs are given in lower doses and more frequently (often daily or multiple times a week) <br>
-Aims to consistently impair tumor growth mechanisms and potentially minimize the chance for cancer cells to recover<br>
-Aims to consistently impair tumor growth mechanisms and potentially minimize the chance for cancer cells to recover<br>
-With a lower dose intensity, patients often experience fewer and less severe side effects<br>

Pathway results for Effect on Cancer / Diseased Cells

Proliferation, Differentiation & Cell State

CSCs↓, 1,   TumCG↓, 1,  

Migration

TSP-1↑, 2,  

Angiogenesis & Vasculature

angioG↓, 2,   Hif1a↓, 1,   VEGF↓, 1,  

Drug Metabolism & Resistance

Dose↝, 3,   Dose↓, 2,   eff↝, 2,   eff↑, 1,  

Clinical Biomarkers

AFP↓, 3,  

Functional Outcomes

OS↑, 3,   Remission↑, 1,   toxicity↓, 3,   TumVol↓, 3,  
Total Targets: 15

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2018Sustained complete response of advanced hepatocellular carcinoma with metronomic capecitabine: a report of three casesGiovanni BrandiPMC6020209https://pmc.ncbi.nlm.nih.gov/articles/PMC6020209/0
2013Metronomic Chemotherapy: Possible Clinical Application in Advanced Hepatocellular CarcinomaTakuji TorimuraPMC3799193https://pmc.ncbi.nlm.nih.gov/articles/PMC3799193/0
2011Metronomic S-1 Chemotherapy and Vandetanib: An Efficacious and Nontoxic Treatment for Hepatocellular CarcinomaHideki IwamotoPMC3050862https://pmc.ncbi.nlm.nih.gov/articles/PMC3050862/0
2010Long-lasting response with metronomic capecitabine in advanced hepatocellular carcinomaPierluigi Ballardini21302626https://pubmed.ncbi.nlm.nih.gov/21302626/0
2010Durable complete response of hepatocellular carcinoma after metronomic capecitabineGiovanni Brandi21388070https://pubmed.ncbi.nlm.nih.gov/21388070/0