tbResList Print — capec capecitabine

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Product

capec capecitabine
Description: <b>Capecitabine</b> is an oral chemotherapy medication used primarily in the treatment of various cancers.<br>
Capecitabine is an antimetabolite chemotherapeutic agent. It's classified as a prodrug, meaning it is metabolized in the body to its active form, 5-fluorouracil (5-FU).<br>
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Once ingested, capecitabine is absorbed and converted through a series of enzymatic reactions into 5-FU. 5-FU then interferes with DNA synthesis and RNA processing by inhibiting enzymes like thymidylate synthase. This disruption of nucleotide production hinders rapid cell division, making it effective against cancer cells that multiply quickly.<br>
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One of the advantages of capecitabine is that it is taken by mouth in tablet form, as opposed to intravenous administration, which can be more convenient for patients<br>

Pathway results for Effect on Cancer / Diseased Cells

Drug Metabolism & Resistance

Dose↝, 3,   eff↝, 1,  

Clinical Biomarkers

AFP↓, 3,  

Functional Outcomes

OS↑, 2,   TumVol↓, 2,  
Total Targets: 5

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2018Sustained complete response of advanced hepatocellular carcinoma with metronomic capecitabine: a report of three casesGiovanni BrandiPMC6020209https://pmc.ncbi.nlm.nih.gov/articles/PMC6020209/0
2010Long-lasting response with metronomic capecitabine in advanced hepatocellular carcinomaPierluigi Ballardini21302626https://pubmed.ncbi.nlm.nih.gov/21302626/0