tbResList Print — AG Arctigenin

Filters: qv=33, qv2=%, rfv=%

Product

AG Arctigenin
Description: <b>Arctigenin</b> is a lignan found in certain plants of the Asteraceae, including the greater burdock (Arctium lappa) and Saussurea heteromalla. It has shown antiviral[1] and anticancer[2] effects in vitro. It is the aglycone of arctiin.<br>

Pathway results for Effect on Cancer / Diseased Cells

Core Metabolism/Glycolysis ⓘ

PI3K/Akt↓, 2,  

Cell Death ⓘ

BAD↓, 1,   Bax:Bcl2↑, 2,  

Kinase & Signal Transduction ⓘ

AMPKα↓, 1,  

Transcription & Epigenetics ⓘ

miR-21↓, 1,  

DNA Damage & Repair ⓘ

NKX3.1↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↓, 1,   STAT3↓, 2,  

Migration ⓘ

miR-148a↓, 1,   miR-19b↓, 1,   TumCMig↓, 2,   TumCP↓, 2,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,   PSA↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

chemoPv↑, 2,   PRAS40↓, 1,  
Total Targets: 20

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2015Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cellsPiwen WangPMC4166488https://pmc.ncbi.nlm.nih.gov/articles/PMC4166488/0
2016Arctigenin in combination with quercetin synergistically enhances the anti-proliferative effect in prostate cancer cellsPiwen WangPMC4314369https://pmc.ncbi.nlm.nih.gov/articles/PMC4314369/0