tbResList Print — meben mebendazole

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Product

meben mebendazole
Description: <b>Mebendazole</b>—an anthelmintic (anti-parasitic) medication<br>
Mebendazole is traditionally used to treat various parasitic worm infections (helminths).<br>
<br>
-Mebendazole has been found to disrupt microtubule formation in cells.<br>
-It might interfere with angiogenesis (the formation of new blood vessels that tumors need to grow)<br>
-Can inhibit the proliferation of various cancer cell lines (such as melanoma, colon cancer, and others)<br>
-May work synergistically with established chemotherapeutic agents.<br>

Pathway results for Effect on Cancer / Diseased Cells

Proliferation, Differentiation & Cell State

TumCG↓, 1,  

Migration

α-tubulin↓, 1,  

Angiogenesis & Vasculature

Hif1a↓, 1,   VEGF↓, 1,  

Functional Outcomes

AntiCan↑, 1,   OS↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2011Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiformeRen-Yuan BaiPMC3158014https://pmc.ncbi.nlm.nih.gov/articles/PMC3158014/0