tbResList Print — Gluc Glucose

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Product

Gluc Glucose
Description: <b>Glucose</b> is a fundamental energy source and its metabolism is essential for all cells, the reprogramming of glucose metabolism in cancer cells underlies many aspects of tumor growth and survival.<br>
-Glucose generally aids cancer cells, but can be used as trojan horse.<br>
-HIF-1 increases the expression of glycolytic enzymes<br>
-Hexokinase II, which catalyzes the first step of glycolysis (often upregulated).<br>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress ⓘ

GSH↓, 1,   lipid-P↑, 1,   ROS↑, 3,   SOD↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

LDH↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 2,  

Migration ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose?, 1,   Dose↝, 1,   eff↑, 5,   eff↝, 4,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

LDH↑, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2022Glucose-Functionalized Silver Nanoparticles as a Potential New Therapy Agent Targeting Hormone-Resistant Prostate Cancer cellsMariana MoraisPMC9489222https://pmc.ncbi.nlm.nih.gov/articles/PMC9489222/0
2017Glucose capped silver nanoparticles induce cell cycle arrest in HeLa cellsElisa Panzarini—https://www.sciencedirect.com/science/article/abs/pii/S088723331730036X0
2014Carbohydrate functionalization of silver nanoparticles modulates cytotoxicity and cellular uptakeDavid C KennedyPMC4275941https://pmc.ncbi.nlm.nih.gov/articles/PMC4275941/0
2010Electrochemical oxidation of glucose on silver nanoparticle-modified composite electrodesHongmei Quan—https://www.sciencedirect.com/science/article/abs/pii/S00134686090145220