tbResList Print — Chol Choline

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Product

Chol Choline
Description: <b>Choline</b> is an essential nutrient with key roles in brain function, liver metabolism, and cell membrane integrity. Its involvement in Alzheimer’s disease (AD) and cancer is increasingly studied due to its roles in methylation, neurotransmitter synthesis, and cell proliferation. <br>
-Choline is a precursor to acetylcholine (ACh), a neurotransmitter critical for memory and cognition. <br>
-AD is associated with a loss of cholinergic neurons, leading to decreased ACh levels. <br>
-Low choline levels may impair memory and accelerate neurodegeneration. <br>
-Dietary choline intake in humans correlates with better cognitive performance and lower risk of dementia in some cohorts.<br>
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Choline and Cancer<br>
-Rapidly dividing cancer cells have high choline demand to support membrane biogenesis.<br>
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lecithin and eggs are example soures of choline<br>

Pathway results for Effect on Cancer / Diseased Cells

Total Targets: 0

Pathway results for Effect on Normal Cells

Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Iron↑, 1,   ROS↓, 1,  

Core Metabolism/Glycolysis ⓘ

homoC↓, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 2,   other∅, 1,   other↑, 2,  

Migration ⓘ

APP↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 2,   ChAT↑, 1,   TrkB↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↑, 1,   eff↑, 3,  

Functional Outcomes ⓘ

cardioP∅, 1,   cognitive↑, 2,   memory↑, 4,   neuroP↑, 1,   Sleep↑, 1,  
Total Targets: 20

Research papers

Year Title Authors PMID Link Flag
2019Eggs and Health Special IssueMaria Luz FernandezPMC5188439https://pmc.ncbi.nlm.nih.gov/articles/PMC5188439/0
2019Lifelong choline supplementation ameliorates Alzheimer's disease pathology and associated cognitive deficits by attenuating microglia activationRamon VelazquezPMC6826123https://pmc.ncbi.nlm.nih.gov/articles/PMC6826123/0
2019B-Vitamin and Choline Supplementation Changes the Ischemic BrainPrerana J. Keerthi—https://www.jyi.org/2019-april/2019/4/1/b-vitamin-and-choline-supplementation-changes-the-ischemic-brain0
2017Association of dietary cholesterol and egg intakes with the risk of incident dementia or Alzheimer disease: the Kuopio Ischaemic Heart Disease Risk Factor StudyMaija Pt Ylilauri28052883https://pubmed.ncbi.nlm.nih.gov/28052883/0
2016Alzheimer's Disease: Targeting the Cholinergic SystemTalita H Ferreira-VieiraPMC4787279https://pmc.ncbi.nlm.nih.gov/articles/PMC4787279/0
2009Choline up-regulates BDNF and down-regulates TrkB neurotrophin receptor in rat cortical cell cultureJan Johansson19424097https://pubmed.ncbi.nlm.nih.gov/19424097/0
1997Acetylcholine, aging, and Alzheimer's diseaseJ L Muir9130295https://pubmed.ncbi.nlm.nih.gov/9130295/0
1982Alzheimer's disease. Correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalitiesG K Wilcock7161627https://pubmed.ncbi.nlm.nih.gov/7161627/0
1982Effects of consumption of choline and lecithin on neurological and cardiovascular systemsJ L Wood6754453https://pubmed.ncbi.nlm.nih.gov/6754453/0