H2S hydrogen sulfide
Description: <b>Hydrogen sulfide (H₂S)</b>, a gaseous signaling molecule, has been implicated in Alzheimer’s disease (AD) pathology with both neuroprotective and neurotoxic roles, depending on concentration, source, and context.<br>
- It was found that the endogenous H2S level in the brain of AD patients was significantly lower than that of normal people. <br>
-A cysteine-rich diet or supplementation with an appropriate amount of N-acetylcysteine is beneficial to the synthesis of H2S in the brain <br>
-Activates Nrf2, upregulates antioxidant genes Reduces oxidative stress, neuroprotective.<br>
-Inhibits NF-κB activation Suppresses inflammatory cytokines like TNF-α, IL-1β<br>
-Reduces Aβ aggregation and toxicity<br>
-Enhances cerebral blood flow<br>
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