tbResList Print — K+ Potassium

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Product

K+ Potassium
Description: <b>Potassium (K⁺)</b>, an essential electrolyte, plays vital roles in cellular function, neuronal signaling, and maintaining membrane potential.<br>
-Source: leafy vegs, legumes, salmon(384mg), banana(358mg), potatoes(russet in skin)(550mg)<br>
-RDA: 4700mg/d (<2% of US adults meet this goal)<br>
AD:<br>
-Low extracellular potassium can lead to increased neuronal calcium influx, oxidative damage, and microglial activation, worsening neurodegeneration.<br>
-Certain potassium channels (e.g., KCNQ) are downregulated in AD, and their activators (like retigabine) have shown neuroprotective effects in preclinical models.<br>
<br>
Cancer:<br>
-K⁺ channels upregulated in many cancers<br>
<br>
Those with kidney problems, may need to decrease potassium intake.<br>
<br>

Pathway results for Effect on Cancer / Diseased Cells

Total Targets: 0

Pathway results for Effect on Normal Cells

Redox & Oxidative Stress ⓘ

4-HNE↓, 1,   ROS↓, 2,  

Core Metabolism/Glycolysis ⓘ

glucose↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 3,   other↝, 3,   other⇅, 1,   other↑, 2,  

Migration ⓘ

AntiAg↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL6↓, 1,   Inflam↓, 2,  

Synaptic & Neurotransmission ⓘ

p‑tau↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   Dose↓, 1,   eff↑, 2,  

Clinical Biomarkers ⓘ

BMD↑, 1,   BP↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 2,   Risk↓, 3,  
Total Targets: 19

Research papers

Year Title Authors PMID Link Flag
2025PotassiumNIH—https://ods.od.nih.gov/factsheets/Potassium-HealthProfessional/0
2020Potassium channels in the neuronal homeostasis and neurodegenerative pathways underlying Alzheimer's disease: An updateChiara Villa31862274https://pubmed.ncbi.nlm.nih.gov/31862274/0
2020Apamin Improves Prefrontal Nicotinic Impairment in Mouse Model of Alzheimer's DiseaseÉ Proulx31188425https://pubmed.ncbi.nlm.nih.gov/31188425/0
2016Rubidium and potassium levels are altered in Alzheimer's disease brain and blood but not in cerebrospinal fluidBlaine R RobertsPMC5109650 khttps://pmc.ncbi.nlm.nih.gov/articles/PMC5109650/0
2015The increased potassium intake improves cognitive performance and attenuates histopathological markers in a model of Alzheimer's diseasePedro Cisternas26391254https://pubmed.ncbi.nlm.nih.gov/26391254/0
2013Na+ and K+ ion imbalances in Alzheimer’s diseaseVictor M VitvitskyPMC3444663https://pmc.ncbi.nlm.nih.gov/articles/PMC3444663/0
2012Sodium and potassium intakes among US adults: NHANES 2003–2008Mary E CogswellPMC3417219https://pmc.ncbi.nlm.nih.gov/articles/PMC3417219/0
2008The effects of boiling and leaching on the content of potassium and other minerals in potatoesP C Bethke18576999https://pubmed.ncbi.nlm.nih.gov/18576999/0
2006Potassium-sparing diuretics might reduce risk of Alzheimer's diseaseJim Casey—https://www.nature.com/articles/ncpneuro01860
1999Abnormal potassium-channel function in platelets in Alzheimer's diseaseDavid Gurwitz—https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(05)74899-6/fulltext0