tbResList Print — VitB6 Vitamin B6,pyridoxine

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Product

VitB6 Vitamin B6,pyridoxine
Description: <b>Vitamin B6 (pyridoxine)</b> has been studied in relation to Alzheimer’s disease (AD) due to its role in brain health, neurotransmitter synthesis, and homocysteine metabolism. <br>
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Biological Role of Vitamin B6
-can act as a potent antioxidant
-Essential for the production of serotonin, dopamine, GABA, and norepinephrine.
-Homocysteine regulation: B6 is a cofactor in the conversion of homocysteine to cysteine.
Elevated homocysteine levels are linked to increased AD risk and brain atrophy.
-Anti-inflammatory effects: B6 may modulate inflammation, a key factor in neurodegeneration.
-Myelin and cognitive function: Involved in myelin formation and synaptic plasticity.
-higher vitamin B6 intakes have been associated with greater grey matter volume

Cognitive support / Homocysteine lowering 10–50 mg/day Often combined with B12 and folate
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Pathway results for Effect on Cancer / Diseased Cells

Total Targets: 0

Pathway results for Effect on Normal Cells

Redox & Oxidative Stress ⓘ

antiOx↑, 2,   SAM-e↓, 1,  

Core Metabolism/Glycolysis ⓘ

homoC↓, 7,  

Transcription & Epigenetics ⓘ

other↑, 5,   other↝, 3,   other↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↝, 1,  

Functional Outcomes ⓘ

cognitive↑, 14,   cognitive∅, 3,   memory↑, 2,   neuroP↑, 3,   Risk↑, 1,   Risk↓, 11,   Risk∅, 3,  
Total Targets: 18

Research papers

Year Title Authors PMID Link Flag
2023Revisiting the Role of Vitamins and Minerals in Alzheimer’s DiseaseHarsh Shah—https://www.mdpi.com/2076-3921/12/2/4150
2017Impact of Diet on Learning, Memory and CognitionAmy C ReicheltPMC5437154https://pmc.ncbi.nlm.nih.gov/articles/PMC54371540
2012Reduced risk of Alzheimer’s disease with high folate intake: The Baltimore Longitudinal Study of AgingMaría M CorradaPMC3375831https://pmc.ncbi.nlm.nih.gov/articles/PMC3375831/0
2009High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trialPaul S AisenPMC2684821https://pmc.ncbi.nlm.nih.gov/articles/PMC2684821/0
2018Homocysteine and Dementia: An International Consensus StatementA David SmithPMC5836397https://pmc.ncbi.nlm.nih.gov/articles/PMC5836397/0
2025Role of B vitamins in modulating homocysteine and metabolic pathways linked to brain atrophy: Metabolomics insights from the VITACOG trialTereza Kacerova—https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.705210
2024Vitamin B6, B12, and Folate’s Influence on Neural Networks in the UK Biobank CohortTianqi LiPMC11243472https://pmc.ncbi.nlm.nih.gov/articles/PMC11243472/0
2022Plants, Plants, and More Plants: Plant-Derived Nutrients and Their Protective Roles in Cognitive Function, Alzheimer's Disease, and Other DementiasHelen DingPMC9414574https://pmc.ncbi.nlm.nih.gov/articles/PMC9414574/0
2021The preventive efficacy of vitamin B supplements on the cognitive decline of elderly adults: a systematic review and meta-analysisShufeng Li—https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-021-02253-30
2020Vitamins in Alzheimer’s Disease—Review of the Latest ReportsAnita MielechPMC7696081https://pmc.ncbi.nlm.nih.gov/articles/PMC7696081/0
2020Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-AnalysisChenbo Zhang32773392https://pubmed.ncbi.nlm.nih.gov/32773392/0
2024Vitamin B6 and vitamin D deficiency co-occurrence in geriatric memory patientsAnna G. Przybelski—https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.125250
2022Vitamin B6, B9, and B12 Intakes and Cognitive Performance in Elders: National Health and Nutrition Examination Survey, 2011–2014Hui XuPMC8962758https://pmc.ncbi.nlm.nih.gov/articles/PMC8962758/0
2017B-Vitamin Intake and Biomarker Status in Relation to Cognitive Decline in Healthy Older Adults in a 4-Year Follow-Up StudyCatherine F HughesPMC5295097https://pmc.ncbi.nlm.nih.gov/articles/PMC5295097/0
2016Vitamin Supplementation as an Adjuvant Treatment for Alzheimer’s DiseaseAdnan Bashir BhattiPMC5028542https://pmc.ncbi.nlm.nih.gov/articles/PMC5028542/0
2014Folate, Vitamin B6 and Vitamin B12 Intake and Mild Cognitive Impairment and Probable Dementia in the Women’s Health Initiative Memory StudyJessica C Agnew-BlaisPMC4312724https://pmc.ncbi.nlm.nih.gov/articles/PMC4312724/0
2014Vitamin B6 prevents cognitive impairment in experimental pneumococcal meningitisTatiana Barichello24903161https://pubmed.ncbi.nlm.nih.gov/24903161/0
2007Vitamin B6, B12, and Folic Acid Supplementation and Cognitive FunctionEthan M. Balk, MD, MPH—https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/4114890