tbResList Print — FLS Flickering Light Stimulation

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Product

FLS Flickering Light Stimulation
Description: <b>Flickering Light Stimulation (FLS)</b>—especially at gamma frequencies (~40 Hz)—has gained attention in recent years as a non-invasive potential therapy for Alzheimer's disease (AD). <br>
- Gamma oscillations are important for cognition, memory, and attention—and are impaired in AD<br>
- Effects in animal models: ↓ Amyloid plaques, ↑ cognition, ↑ microglial activity<br>
- In Cognito Therapeutics' trials, participants use a wearable device (like glasses) that delivers flickering light and sound simultaneously, with eyes open.<br>
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Pathway results for Effect on Cancer / Diseased Cells

Total Targets: 0

Pathway results for Effect on Normal Cells

Transcription & Epigenetics ⓘ

other↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Functional Outcomes ⓘ

cognitive↑, 2,   Sleep↑, 1,  
Total Targets: 6

Research papers

Year Title Authors PMID Link Flag
2024Improvement of olfactory function in AD mice mediated by immune responses under 40 Hz light flickeringJiaying Hu39218292https://pubmed.ncbi.nlm.nih.gov/39218292/0
2022Combined effects of aerobic exercise and 40-Hz light flicker exposure on early cognitive impairments in Alzheimer's disease of 3×Tg miceSang-Seo Park35201933https://pubmed.ncbi.nlm.nih.gov/35201933/0
2021Sensory-Evoked 40-Hz Gamma Oscillation Improves Sleep and Daily Living Activities in Alzheimer’s Disease PatientsAylin CimenserPMC8500065https://pmc.ncbi.nlm.nih.gov/articles/PMC8500065/0