tbResList Print — Silicon Silicic Acid

Filters: qv=362, qv2=%, rfv=%

Product

Silicon Silicic Acid
Description: <b>Silicon</b> and its derivatives—especially silicic acid—have been studied for potential neuroprotective effects, including in the context of Alzheimer’s disease (AD).<br>
-Silicon is a trace element involved in bone health, connective tissue, and possibly cognitive function.<br>
-It is most bioavailable in the form of orthosilicic acid (OSA), a soluble and absorbable form often found in drinking water or supplements<br>
-Silicon binds aluminum, forming hydroxyaluminosilicates that are poorly absorbed by the gut and are more easily excreted.<br>
-Silicic acid may protect neurons from oxidative and inflammatory stress, mechanisms relevant to AD.<br>



Pathway results for Effect on Cancer / Diseased Cells

Total Targets: 0

Pathway results for Effect on Normal Cells

Redox & Oxidative Stress ⓘ

MDA↓, 1,   ROS↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 3,   other∅, 1,   other↑, 3,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   Dose↝, 1,   Dose?, 1,   Dose↑, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,   creat↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 5,   cognitive↝, 1,   neuroP↑, 6,   Risk↓, 2,  
Total Targets: 17

Research papers

Year Title Authors PMID Link Flag
2024Interference of Parenteral Nutrition Components in Silicon-Mediated Protection Against Aluminum BioaccumulationSimone Noremberg Kunz37924413https://pubmed.ncbi.nlm.nih.gov/37924413/0
2023Garden Cress (Lepidium sativum) Seeds Ameliorated Aluminum-Induced Alzheimer Disease in Rats Through Antioxidant, Anti-Inflammatory, and Antiapoptotic EffectsMaha J BalgoonPMC10106954https://pmc.ncbi.nlm.nih.gov/articles/PMC10106954/0
2020Oral Administration of Si-Based Agent Attenuates Oxidative Stress and Ischemia-Reperfusion Injury in a Rat Model: A Novel Hydrogen Administration MethodMasataka KawamuraPMC7099649https://pmc.ncbi.nlm.nih.gov/articles/PMC7099649/0
2017Aluminum Should Now Be Considered a Primary Etiological Factor in Alzheimer’s DiseaseChristopher ExleyPMC6159653https://pmc.ncbi.nlm.nih.gov/articles/PMC6159653/0
2015Silicon as Versatile Player in Plant and Human Biology: Overlooked and Poorly UnderstoodMuhammad Ansar FarooqPMC4641902https://pmc.ncbi.nlm.nih.gov/articles/PMC4641902/0
2013Silicon-rich mineral water as a non-invasive test of the 'aluminum hypothesis' in Alzheimer's diseaseSamantha Davenward22976072https://pubmed.ncbi.nlm.nih.gov/22976072/0
2011Oral silicon supplementation: an effective therapy for preventing oral aluminum absorption and retention in mammalsJosé L Domingo21198634https://pubmed.ncbi.nlm.nih.gov/21198634/0
2008Relation between aluminum concentrations in drinking water and Alzheimer's disease: an 8-year follow-up studyVirginie RondeauPMC2215380https://pmc.ncbi.nlm.nih.gov/articles/PMC2215380/0
2007The potential influence of silica present in drinking water on Alzheimer's disease and associated disordersS Gillette Guyonnet17435954https://pubmed.ncbi.nlm.nih.gov/17435954/0
1998Silicon reduces aluminum accumulation in rats: relevance to the aluminum hypothesis of Alzheimer diseaseM Bellés9651136https://pubmed.ncbi.nlm.nih.gov/9651136/0
1996Silica and aluminum in drinking water and cognitive impairment in the elderlyH Jacqmin-Gadda8728442https://pubmed.ncbi.nlm.nih.gov/8728442/0