tbResList Print — SY Safflower yellow

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Product

SY Safflower yellow
Description: <b>Safflower yellow (SY)</b>, a natural pigment extracted from the petals of Carthamus tinctorius (safflower), has shown neuroprotective effects in several models of neurodegenerative diseases, including Alzheimer’s disease (AD).<br>
-SY was found to improve learning and memory in AD animal model<br>
-SY increases SOD and decreases MDA, a marker of lipid peroxidation<br>
-SY downregulates pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α in brain tissues.<br>
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Pathway results for Effect on Cancer / Diseased Cells

Total Targets: 0

Pathway results for Effect on Normal Cells

Redox & Oxidative Stress ⓘ

GPx↑, 1,   MDA↓, 1,   ROS↓, 1,   SOD↓, 1,  

Core Metabolism/Glycolysis ⓘ

CREB↑, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BDNF↑, 1,   ChAT↑, 1,   TrkB↑, 1,  

Functional Outcomes ⓘ

memory↑, 1,  
Total Targets: 10

Research papers

Year Title Authors PMID Link Flag
2025Safflower yellow alleviates cognitive impairment in mice by modulating cholinergic system function, oxidative stress, and CREB/BDNF/TrkB signaling pathwayYanqiang Qi39461389https://pubmed.ncbi.nlm.nih.gov/39461389/0