tbResList Print — Cyste Cysteamine

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Product

Cyste Cysteamine
Description: <b>Cysteamine</b> is a prescription drug, approved for treating cystinosis<br>
-it is not sold over-the-counter as a dietary supplement.<br>
-In contrast, related compounds like N-acetylcysteine (NAC) and pantethine are widely available supplements and can indirectly support cysteamine-related pathways (e.g., antioxidant defenses and CoA metabolism).<br>
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-Pantethine: Precursor to CoA, which breaks down into cysteamine<br>
-Pantothenic Acid (Vitamin B5): Required for CoA synthesis<br>
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-Cysteamine increases glutathione (GSH) levels, reducing oxidative stress, a major contributor to AD pathology.<br>
-Some studies suggest that cysteamine increases brain-derived neurotrophic factor (BDNF) levels<br>
-Cysteamine has been observed to reduce amyloid plaque burden in animal models of AD.<br>
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Pathway results for Effect on Cancer / Diseased Cells

Total Targets: 0

Pathway results for Effect on Normal Cells

Redox & Oxidative Stress

ARE↑, 1,   GSH↑, 1,   NRF2↑, 1,  

Transcription & Epigenetics

other↝, 2,  

Synaptic & Neurotransmission

BDNF↑, 2,  

Functional Outcomes

neuroP↑, 3,  
Total Targets: 6

Research papers

Year Title Authors PMID Link Flag
2010Cystamine metabolism and brain transport properties: clinical implications for neurodegenerative diseasesMélanie Bousquet20569301https://pubmed.ncbi.nlm.nih.gov/20569301/0
2010Cystamine protects from 3-nitropropionic acid lesioning via induction of nf-e2 related factor 2 mediated transcriptionMarcus J CalkinsPMC2885467https://pmc.ncbi.nlm.nih.gov/articles/PMC2885467/0
2006Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminaseMaria Borrell-PagèsPMC1430359https://pmc.ncbi.nlm.nih.gov/articles/PMC1430359/0