tbResList Print — PEG polyethylene glycol

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Product

PEG polyethylene glycol
Description: <b> PEG <b> polyethylene glycol often used for nano particle stabilization.
-Prevents aggregation, reduces opsonization<b>
-Increases half-life and stability<b>
-improves tumor targeting (EPR effect)<b>
<b>
repeated PEG exposure can trigger anti-PEG antibodies (found in ~20–40% of humans), which may Reduce therapeutic effectiveness <b>

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   LDH↓, 1,  

Cell Death ⓘ

Apoptosis↑, 2,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 2,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   LDH↓, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells

Redox & Oxidative Stress ⓘ

GPx↑, 1,   GSH↑, 1,   SOD↑, 1,   VitC↑, 1,   VitE↑, 1,  

Hormonal & Nuclear Receptors ⓘ

GR↑, 1,  
Total Targets: 6

Research papers

Year Title Authors PMID Link Flag
2023Anti-cancer potential of selenium-chitosan-polyethylene glycol-carvacrol nanocomposites in multiple myeloma U266 cellsHaixi Zhang—https://onlinelibrary.wiley.com/doi/abs/10.1002/jbt.234240
2022Anticancer effect of selenium/chitosan/polyethylene glycol/allyl isothiocyanate nanocomposites against diethylnitrosamine-induced liver cancer in ratsCheng LiPMC9280227https://pmc.ncbi.nlm.nih.gov/articles/PMC9280227/0