tbResList Print — OLEC Oleocanthal

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Product

OLEC Oleocanthal
Description: <b>Oleocanthal</b> is a phenolic compound found ONLY in extra-virgin olive oil (EVOO).<br>
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It has strong anti-inflammatory activity (similar to ibuprofen-like COX inhibition).
In multiple cell and animal studies, it:
-selectively induces lysosomal membrane permeabilization in cancer cells, leading to rapid cell death
-inhibits tumor proliferation and metastasis pathways
-reduces HER2 signaling
-slows colorectal, breast, and prostate cancer progression in models

It has indirect CSC targeting

Not available as a supplement
-it is unstable outside the oil.
-some companies sell high-oleocanthal EVOO
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Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress

ROS↑, 1,  

Cell Death

p‑Akt↓, 1,   Apoptosis↑, 2,   Bcl-2↓, 1,   HGF/c-Met↝, 1,  

Proliferation, Differentiation & Cell State

cMET↓, 1,   EMT↓, 1,   ERK↓, 1,   mTOR↓, 1,   STAT3↓, 2,   STAT3↝, 1,  

Migration

TumCP↓, 1,  

Angiogenesis & Vasculature

angioG↓, 1,  

Immune & Inflammatory Signaling

COX2↓, 1,   PSA↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance

BioAv↓, 1,   eff↑, 1,  

Clinical Biomarkers

PSA↓, 1,  

Functional Outcomes

AntiCan↑, 1,  
Total Targets: 20

Pathway results for Effect on Normal Cells

Redox & Oxidative Stress

antiOx↓, 1,   ROS↓, 1,  

Cell Death

iNOS↓, 1,  

Migration

AntiAg↑, 1,  

Immune & Inflammatory Signaling

COX2↓, 1,   IL1β↓, 1,   Inflam↓, 2,   TNF-α↓, 1,  

Clinical Biomarkers

GutMicro↝, 1,  

Functional Outcomes

QoL↑, 1,  
Total Targets: 10

Research papers

Year Title Authors PMID Link Flag
2025Oleocanthal as a Multifunctional Anti-Cancer Agent: Mechanistic Insights, Advanced Delivery Strategies, and Synergies for Precision OncologyShirin JannatiPMC12193433https://pmc.ncbi.nlm.nih.gov/articles/PMC12193433/0
2023Oleocanthal, an Antioxidant Phenolic Compound in Extra Virgin Olive Oil (EVOO): A Comprehensive Systematic Review of Its Potential in Inflammation and CancerMaría González-Rodríguezhttps://www.researchgate.net/publication/376546222_Oleocanthal_an_Antioxidant_Phenolic_Compound_in_Extra_Virgin_Olive_Oil_EVOO_A_Comprehensive_Systematic_Review_of_Its_Potential_in_Inflammation_and_Cancer0
2022The Effect of Dietary Intervention With High-Oleocanthal and Oleacein Olive Oil in Patients With Early-Stage Chronic Lymphocytic Leukemia: A Pilot Randomized TrialAndrea Paola Rojas Gilhttps://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.810249/full0
2020Anticancer molecular mechanisms of oleocanthalMohammed El Haouari32449241https://pubmed.ncbi.nlm.nih.gov/32449241/0