Description: <b>Irinotecan</b> is a chemotherapy drug widely used to treat several solid tumors. It is a semisynthetic camptothecin derivative and functions primarily as a topoisomerase I inhibitor.<br>
-Active metabolite: SN-38 (much more potent than irinotecan itself)<br>
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Common Regimens<br>
Regimen Components<br>
FOLFIRI Folinic acid + 5-FU + Irinotecan<br>
FOLFIRINOX 5-FU + Leucovorin + Irinotecan + Oxaliplatin<br>
XELIRI / CAPIRI Capecitabine + Irinotecan<br>
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Potential strategies to sensitize tumors to irinotecan:
Strategy Rationale
GSH depletion Reduces detox of SN-38
PRDX/TXNRD stress Lowers redox buffering
Glycolysis inhibition Limits repair energy
PEMF / AgNPs ↑ ROS, ↑ drug uptake
Timing selenium Avoid boosting antioxidant defenses during therapy
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Report of combining <a href="https://nestronics.ca/dbx/tbResEdit.php?rid=4734">CPT-11 and SeNPs</a> to increase NRF2 in normal cells(chemoprotective) and decrease NRF2 in cancer cells(chemosentization).