Description: <b>Glutathione</b> = GSH (reduced form)</br>
Oxidized glutathione = GSSG</br>
GSH/GSSG ratio = key indicator of cellular redox state</br>
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-Neutralizes H₂O₂ and lipid peroxides</br>
-Maintains redox homeostasis</br>
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Most cancers show:</br>
-Elevated GSH levels</br>
-Increased GSH synthesis and recycling</br>
-High GSH/GSSG ratio</br>
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This supports:</br>
-Survival under oxidative stress</br>
-Resistance to chemotherapy and radiation</br>
-Detoxification of drugs (e.g., irinotecan, cisplatin)</br>
-Cancer cells often develop a “GSH addiction”.</br>
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Natural Products Affecting GSH
Compound Effect
Curcumin ↓ GSH in cancer cells
Sulforaphane Transient NRF2 activation → later depletion
Resveratrol Disrupts GSH recycling
Quercetin Consumes GSH during detox
Selenium compounds Dose-dependent: support GPX or induce redox stress
High-dose Vitamin C Depletes GSH via ROS overload
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