tbResList Print — BRU brusatol

Filters: qv=385, qv2=%, rfv=%

Product

BRU brusatol
Description: <b>Brusatol</b> is a quassinoid (highly oxygenated triterpenoid derivative) isolated from Brucea javanica. It is best known in oncology research as a potent functional inhibitor of the Nrf2 pathway, which places it at the center of redox regulation, chemoresistance, and mitochondrial stress in cancer cells.<br>
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Pathway results for Effect on Cancer / Diseased Cells

Total Targets: 0

Pathway results for Effect on Normal Cells

Redox & Oxidative Stress

NRF2↓, 1,  
Total Targets: 1

Research papers

Year Title Authors PMID Link Flag
2022An update of Nrf2 activators and inhibitors in cancer prevention/promotionFarhad PouremamaliPMC9245222https://pmc.ncbi.nlm.nih.gov/articles/PMC9245222/0