Description: <b>Xanthohumol</b> is a prenylated chalcone flavonoid derived from hops (Humulus lupulus).<br>
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Commonly described actions include:
-Inflammation suppression: attenuation of NF-κB / STAT3 signaling
-Cell-cycle and survival effects: pro-apoptotic signaling, mitochondrial stress
-Angiogenesis inhibition: reduced VEGF signaling in models
-Metabolic stress modulation: interference with lipid and glucose handling
-Redox effects: antioxidant at low/physiologic exposure; pro-oxidant stress at higher concentrations
Importantly, dose, timing, and cellular context determine which mechanism dominates.
Xanthohumol is best described as chemopreventive or chemo-sensitizing, not chemoprotective:
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