tbResList Print — ENZ enzalutamide

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Product

ENZ enzalutamide
Description: <b>Enzalutamide</b> is a second-generation androgen receptor (AR) signaling inhibitor used primarily in prostate cancer, especially in castration-resistant prostate cancer (CRPC).<br>

Pathway results for Effect on Cancer / Diseased Cells

DNA Damage & Repair ⓘ

NKX3.1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

AR-FL↓, 1,   AR-V7↑, 1,  

Migration ⓘ

hnRNPA1↓, 1,  

Immune & Inflammatory Signaling ⓘ

PSA↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   FKBP5↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

TumVol↓, 1,   UBE2C↓, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2017Quercetin targets hnRNPA1 to overcome enzalutamide resistance in prostate cancer cellsRamakumar TummalaPMC5716891https://pmc.ncbi.nlm.nih.gov/articles/PMC5716891/0