tbResList Print — Ome Omeprazole

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Product

Ome Omeprazole
Description: <b>Omeprazole</b> is a proton pump inhibitor (PPI) used mainly for GERD, ulcers, and other acid-related disorders. Pharmacologically, it is a benzimidazole prodrug that becomes active in an acidic environment and irreversibly inhibits the gastric H+/K+-ATPase proton pump, reducing stomach acid secretion.<br>

-Possible long-term cancer risk associations, especially for gastric cancer in observational studies
-Possible Direct anticancer or chemosensitizing effects in preclinical models.

Pathway results for Effect on Cancer / Diseased Cells

Total Targets: 0

Pathway results for Effect on Normal Cells

Core Metabolism/Glycolysis

CYP3A4↑, 1,  

Transcription & Epigenetics

other?, 1,  

Barriers & Transport

P-gp↑, 1,  
Total Targets: 3

Research papers

Year Title Authors PMID Link Flag
2019Effects of astragaloside IV on the pharmacokinetics of omeprazole in ratsWei Liu—https://www.tandfonline.com/doi/full/10.1080/13880209.2019.16368280