tbResList Print — CEL Celecoxib

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Product

CEL Celecoxib
Features: NSAID
Description: <b>Celecoxib</b> inhibits the formation of prostaglandins: used primarily to treat pain and other symptoms of osteoarthritis, rheumatoid arthritis, joint and musculoskeletal conditions.<br>

Pathway results for Effect on Cancer / Diseased Cells

Transcription & Epigenetics ⓘ

miR-145↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,  

Migration ⓘ

SMAD3↓, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   NF-kB↓, 1,   p65↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells

Total Targets: 0

Research papers

Year Title Authors PMID Link Flag
2019Celecoxib inhibits the epithelial-to-mesenchymal transition in bladder cancer via the miRNA-145/TGFBR2/Smad3 axisXiaoqiang LiuPMC6605707https://pmc.ncbi.nlm.nih.gov/articles/PMC6605707/0
2017Celecoxib Down-Regulates the Hypoxia-Induced Expression of HIF-1α and VEGF Through the PI3K/AKT Pathway in Retinal Pigment Epithelial CellsYi-Zhou Sun29216640https://pubmed.ncbi.nlm.nih.gov/29216640/0
2008Celecoxib inhibited activation of NF-κB and expression of NF-κB P65 protein in HepG2 cellsDong Lu—https://www.researchgate.net/publication/283137204_Celecoxib_inhibited_activation_of_NF-kB_and_expression_of_NF-kB_P65_protein_in_HepG2_cells0