Description: <p><b>Punica granatum</b> - Pomegranate</p>
<p><b>Type:</b> Botanical extract / polyphenol- and ellagitannin-rich fruit</p>
<p><b>Active Constituents:</b> Punicalagins, ellagic acid, ellagitannins, anthocyanins, flavonoids, and other polyphenols. Gut metabolism can generate urolithins from ellagitannins.</p>
<p><b>Function:</b> Punica granatum extracts exhibit antioxidant, anti-inflammatory, antiproliferative, pro-apoptotic, antiangiogenic, and metabolic effects. Biological activity varies among juice, peel, seed, and standardized extract preparations.</p>
<p><b>Cancer:</b> Experimental and clinical research has investigated pomegranate in prostate, breast, colorectal, and other cancers. Reported mechanisms include inhibition of proliferation, inflammation, angiogenesis, invasion, and metastasis and promotion of apoptosis.</p>
<p><b>Alzheimer's Disease:</b> Experimental studies suggest neuroprotective activity through reduction of oxidative stress, neuroinflammation, amyloid-related pathology, and synaptic dysfunction. Pomegranate-derived polyphenols and their metabolites may contribute to these effects.</p>