Description: <p><b>Isoquercitrin</b> - Quercetin-3-O-Glucoside</p>
<p><b>Alternative Names:</b> Isoquercetin, quercetin-3-O-glucoside, quercetin-3-O-β-D-glucopyranoside, Q3G, IQ</p>
<p><b>Type:</b> Flavonol glycoside / quercetin glycoside / natural phytochemical</p>
<p><b>Sources:</b> Naturally present in numerous medicinal plants, fruits, vegetables, and plant-derived foods. Isoquercitrin can also be produced from rutin by enzymatic removal of the rhamnose residue.</p>
<p><b>Function:</b> Isoquercitrin is a bioactive quercetin glycoside with antioxidant, anti-inflammatory, anticancer, metabolic, and neuroprotective effects. Reported mechanisms include modulation of Nrf2/ARE, NF-κB, JAK/STAT3, PI3K/AKT, MAPK, AMPK, Wnt signaling, oxidative stress, and programmed cell death.</p>
<p><b>Cancer:</b> Preclinical studies demonstrate inhibition of cancer-cell proliferation, survival, migration, and tumor-associated signaling together with induction of apoptosis and modulation of oxidative stress. Anticancer mechanisms include regulation of Wnt, MAPK, JAK/STAT3, PI3K/AKT, NF-κB, and related signaling pathways.</p>
<p><b>Alzheimer's Disease:</b> Preclinical studies indicate neuroprotective activity, including improved learning and memory in amyloid-β-induced models and reduction of oxidative and inflammatory neuronal injury.</p>