Description: <p><b>Butein</b> - 2',3,4,4'-Tetrahydroxychalcone</p>
<p><b>Type:</b> Chalcone / polyphenolic flavonoid-related compound</p>
<p><b>Function:</b> Butein is a chalcone/polyphenol found in plants such as Rhus verniciflua, Dalbergia odorifera, and Butea monosperma. Butein is a naturally occurring chalcone with antioxidant, anti-inflammatory, and antiproliferative activity. It can modulate signaling pathways including STAT3, NF-κB, PI3K/AKT, MAPK, and redox-sensitive pathways and can influence apoptosis, cell-cycle progression, migration, invasion, and angiogenesis.</p>
<p><b>Cancer:</b> Preclinical studies show broad anticancer activity, including inhibition of proliferation, migration, invasion, epithelial-mesenchymal transition, angiogenesis, and pro-survival signaling, together with induction of apoptosis and cell-cycle arrest in multiple cancer models.</p>