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Bor Boron

Features: micronutrient

Description: Boron is a trace mineral. 
Used in treating yeast infections, improving athletic performance, or preventing osteoporosis. 
 
Current research suggests that boric acid can modulate intercellular calcium levels—with potential implications for cancer therapy—by: 
-Altering calcium channel activity and calcium influx, 
-Modifying downstream calcium-dependent signaling, and 
-Inducing apoptotic pathways preferentially in cancer cells due to their altered calcium handling dynamics. 
Abnormal increases in [Ca²⁺]ᵢ can trigger mitochondrial dysfunction and activate calcium-dependent apoptotic pathways. Boric acid has been observed in some cell culture studies to induce apoptosis in cancer cells. 
In normal cells, modest changes in [Ca²⁺]ᵢ induced by boric acid may not reach a threshold that triggers apoptosis or other stress responses. This could lead to a relative sparing of normal cells compared to cancer cells. 
 
Pathways: 
1.Calcium Signaling Pathway 
In many cases, boron appears to normalize dysregulated calcium levels in cancer cells, often leading to an increase in calcium levels that can trigger calcium-dependent apoptotic pathways.
2.Apoptotic Pathways (Intrinsic and Extrinsic). 
Direction of Modulation: 
• Boron compounds may enhance the activation of apoptotic cascades. 
• Typically, an increase in intracellular calcium (as noted above) can further lead to mitochondrial dysfunction, cytochrome c release, and subsequent caspase activation, thereby promoting apoptosis. 
3.PI3K/AKT/mTOR Pathway 
• Some studies indicate that boron-containing compounds can inhibit this pathway. 
• Inhibition of PI3K/AKT/mTOR signaling reduces survival signals and can decrease cellular proliferation and growth in tumor cell. 
4.MAPK/ERK Pathway 
Boron may modulate the MAPK/ERK cascade by either dampening overactive mitogenic signals or altering the stress response. 
• This modulation can lead to reduced proliferation signals and may promote cell cycle arrest in cancer cells. 
5.NF-κB Signaling Pathway 
• Some reports indicate that boron compounds can suppress NF-κB activity. 
• This suppression might be achieved indirectly through modulation of upstream signals (such as changes in calcium or the cellular redox status) leading to decreased transcription of pro-survival and pro-inflammatory genes. 
6.Wnt/β-Catenin Pathway 
• Inhibition of Wnt/β-catenin signaling may interfere with proliferation and the maintenance of cancer stem cell populations. 
 
ROS: 
-ROS induction may be dose related. 
-Some studies report that when boron compounds are combined with other treatments (like chemotherapy or radiotherapy), there is a synergistic increase in ROS generation. 

Boron’s effects in a cancer context generally lean toward: 
• Normalizing dysregulated calcium signaling to push cells toward apoptotic death 
• Inhibiting pro-survival pathways such as <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4712861/">PI3K/AKT/mTOR and NF-κB</a> 
 
(1) is essential for the growth and maintenance of bone; 
(2) greatly improves wound healing; 
(3) beneficially impacts the body's use of estrogen, testosterone, and vitamin D; 
(4) boosts magnesium absorption; 
(5) reduces levels of inflammatory biomarkers, such as high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor α (TNF-α); 
(6) raises levels of antioxidant enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase; 
(7) protects against pesticide-induced oxidative stress and heavy-metal toxicity; 
(8) improves the brains electrical activity, cognitive performance, and short-term memory for elders; 
(9) influences the formation and activity of key biomolecules, such as S-adenosyl methionine (SAM-e) and nicotinamide adenine dinucleotide (NAD(+)); 
(10) has demonstrated preventive and therapeutic effects in a number of cancers, such as prostate, cervical, and lung cancers, and multiple and non-Hodgkin's lymphoma; and 
(11) may help ameliorate the adverse effects of traditional chemotherapeutic agents. 

 
-Note <a href="tbResList.php?qv=46&tsv=1109&wNotes=on&exSp=open">half-life</a> 21 hrs average 
<a href="tbResList.php?qv=46&tsv=792&wNotes=on&exSp=open">BioAv</a> very high, 85-100%
 
Pathways: 


- induce
<a href="tbResList.php?qv=46&tsv=275&wNotes=on">ROS</a> productionin cancer cells, while reducing ROS in normal cells. 
- ROS↑ related:
<a href="tbResList.php?qv=46&tsv=197&wNotes=on&word=MMP↓">MMP↓</a>(ΔΨm),
<a href="tbResList.php?qv=46&tsv=103&wNotes=on">ER Stress↑</a>,
<a href="tbResList.php?qv=46&tsv=459&wNotes=on">UPR↑</a>,
<a href="tbResList.php?qv=46&tsv=356&wNotes=on">GRP78↑</a>,
<a href="tbResList.php?qv=46&tsv=38&wNotes=on&word=Ca+2↑">Ca+2↑</a>,(contrary)
<a href="tbResList.php?qv=46&tsv=77&wNotes=on">Cyt‑c↑</a>,
<a href="tbResList.php?qv=46&wNotes=on&word=Casp">Caspases↑</a>,
<a href="tbResList.php?qv=46&tsv=82&wNotes=on&word=DNAdam↑">DNA damage↑</a>,
<a href="tbResList.php?qv=46&tsv=239&wNotes=on">cl-PARP↑</a>,(contrary)
<a href="tbResList.php?qv=46&wNotes=on&word=HSP">HSP↓</a>,


 


- Debateable if Lowers AntiOxidant defense in Cancer Cells:
<a href="tbResList.php?qv=46&tsv=226&wNotes=on&word=NRF2">NRF2↓</a>(most contrary),

<a href="tbResList.php?qv=46&tsv=298&wNotes=on&word=SOD">SOD↓</a>(some contrary),
<a href="tbResList.php?qv=46&tsv=137&wNotes=on&word=GSH↓">GSH↓</a>,
<a href="tbResList.php?qv=46&tsv=46&wNotes=on">Catalase↓</a>(some contrary),
<a href="tbResList.php?qv=46&tsv=597&wNotes=on">HO1↓</a>(contrary),
<a href="tbResList.php?qv=46&wNotes=on&word=GPx">GPx↓</a>(some contrary)
 

- Raises
<a href="tbResList.php?qv=46&tsv=1103&wNotes=on&word=antiOx↑">AntiOxidant</a>
defense in Normal Cells:
<a href="tbResList.php?qv=46&tsv=275&wNotes=on&word=ROS↓">ROS↓</a>,
<a href="tbResList.php?qv=46&tsv=226&wNotes=on&word=NRF2">NRF2↑</a>,
<a href="tbResList.php?qv=46&tsv=298&wNotes=on&word=SOD↑">SOD↑</a>,
<a href="tbResList.php?qv=46&tsv=137&wNotes=on&word=GSH↑">GSH↑</a>,
<a href="tbResList.php?qv=46&tsv=46&wNotes=on&word=Catalase↑">Catalase↑</a>,

 


- lowers
<a href="tbResList.php?qv=46&tsv=953&wNotes=on&word=Inflam">Inflammation</a> :
<a href="tbResList.php?qv=46&tsv=214&wNotes=on&word=NF-kB↓">NF-kB↓</a>,
<a href="tbResList.php?qv=46&tsv=66&wNotes=on&word=COX2↓">COX2↓</a>,
 Pro-Inflammatory Cytokines :
<a href="tbResList.php?qv=46&tsv=908&wNotes=on&word=NLRP3↓">NLRP3↓</a>,
<a href="tbResList.php?qv=46&tsv=978&wNotes=on&word=IL1β↓">IL-1β↓</a>,
<a href="tbResList.php?qv=46&tsv=309&wNotes=on&word=TNF-α↓">TNF-α↓</a>,
<a href="tbResList.php?qv=46&tsv=158&wNotes=on&word=IL6↓">IL-6↓</a>,

 


- inhibit Growth/Metastases :
<a href="tbResList.php?qv=46&tsv=604&wNotes=on">TumMeta↓</a>,
<a href="tbResList.php?qv=46&tsv=323&wNotes=on">TumCG↓</a>,
<a href="tbResList.php?qv=46&tsv=96&wNotes=on">EMT↓</a>,




<a href="tbResList.php?qv=46&tsv=415&wNotes=on">IGF-1↓</a>,

<a href="tbResList.php?qv=46&tsv=334&wNotes=on">VEGF↓</a>,


<a href="tbResList.php?qv=46&tsv=273&wNotes=on">RhoA↓</a>,
<a href="tbResList.php?qv=46&tsv=214&wNotes=on">NF-κB↓</a>,


<a href="tbResList.php?qv=46&tsv=304&wNotes=on">TGF-β↓</a>,
<a href="tbResList.php?qv=46&tsv=719&wNotes=on">α-SMA↓</a>,
<a href="tbResList.php?qv=46&tsv=105&wNotes=on">ERK↓</a>

 


- reactivate genes thereby inhibiting cancer cell growth :
<a href="tbResList.php?qv=46&tsv=140&wNotes=on">HDAC↓</a>,


<a href="tbResList.php?qv=46&tsv=236&wNotes=on">P53↑</a>,
<a href="tbResList.php?qv=46&wNotes=on&word=HSP">HSP↓</a>,


 


- some indication of Cell cycle arrest :
<a href="tbResList.php?qv=46&tsv=322&wNotes=on">TumCCA↑</a>,
<a href="tbResList.php?qv=46&tsv=73&wNotes=on">cyclin D1↓</a>,
<a href="tbResList.php?qv=46&tsv=378&wNotes=on">cyclin E↓</a>,
<a href="tbResList.php?qv=46&tsv=467&wNotes=on">CDK2↓</a>,
<a href="tbResList.php?qv=46&tsv=894&wNotes=on">CDK4↓</a>,
<a href="tbResList.php?qv=46&tsv=895&wNotes=on">CDK6↓</a>,
 


- inhibits Migration/Invasion :
<a href="tbResList.php?qv=46&tsv=326&wNotes=on">TumCMig↓</a>,
<a href="tbResList.php?qv=46&tsv=324&wNotes=on">TumCI↓</a>,
<a href="tbResList.php?qv=46&tsv=309&wNotes=on&word=TNF-α↓">TNF-α↓</a>, 

<a href="tbResList.php?qv=46&tsv=105&wNotes=on">ERK↓</a>,
<a href="tbResList.php?qv=46&tsv=96&wNotes=on">EMT↓</a>,


 


- small indication of inhibiting
<a href="tbResList.php?qv=46&tsv=129&wNotes=on">glycolysis</a>
:
<a href="tbResList.php?qv=46&tsv=143&wNotes=on">HIF-1α↓</a>,

<a href="tbResList.php?qv=46&tsv=35&wNotes=on">cMyc↓</a>,








<a href="tbResList.php?qv=46&tsv=356&wNotes=on">GRP78↑</a>,
<a href="tbResList.php?qv=46&tsv=1278&wNotes=on">Glucose↓</a>,

 


- small indication of inhibiting
<a href="tbResList.php?qv=46&tsv=447&wNotes=on">angiogenesis↓</a> :
<a href="tbResList.php?qv=46&tsv=334&wNotes=on">VEGF↓</a>,
<a href="tbResList.php?qv=46&tsv=143&wNotes=on">HIF-1α↓</a>,



<a href="tbResList.php?qv=46&tsv=94&wNotes=on&word=EGFR↓">EGFR↓</a>,

 





- Others: <a href="tbResList.php?qv=46&tsv=252&wNotes=on">PI3K↓</a>,
<a href="tbResList.php?qv=46&tsv=4&wNotes=on">AKT↓</a>,
<a href="tbResList.php?qv=46&wNotes=on&word=JAK">JAK↓</a>,
<a href="tbResList.php?qv=46&wNotes=on&word=STAT">STAT↓</a>,
<a href="tbResList.php?qv=46&tsv=377&wNotes=on">Wnt↓</a>,
<a href="tbResList.php?qv=46&tsv=342&wNotes=on">β-catenin↓</a>,
<a href="tbResList.php?qv=46&tsv=9&wNotes=on">AMPK</a>,

<a href="tbResList.php?qv=46&tsv=105&wNotes=on">ERK↓</a>,



- <a href="tbResList.php?qv=46&wNotes=on&word=SREBP">SREBP</a> (related to cholesterol). 


- Synergies:
<a href="tbResList.php?qv=46&tsv=1106&wNotes=on">chemo-sensitization</a>,
<a href="tbResList.php?qv=46&tsv=1171&wNotes=on">chemoProtective</a>,
<a href="tbResList.php?qv=46&tsv=1107&wNotes=on">RadioSensitizer</a>,
<a href="tbResList.php?qv=46&tsv=1185&wNotes=on">RadioProtective</a>,
<a href="tbResList.php?qv=46&tsv=961&esv=2&wNotes=on&exSp=open">Others(review target notes)</a>,
<a href="tbResList.php?qv=46&tsv=1105&wNotes=on">Neuroprotective</a>,
<a href="tbResList.php?qv=46&tsv=557&wNotes=on">Cognitive</a>,
<a href="tbResList.php?qv=46&tsv=1175&wNotes=on">Renoprotection</a>,
<a href="tbResList.php?qv=46&tsv=1179&wNotes=on">Hepatoprotective</a>,
<a href="tbResList.php?&qv=46&tsv=1188&wNotes=on">CardioProtective</a>,

 
 

- Selectivity:
<a href="tbResList.php?qv=46&tsv=1110&wNotes=on">Cancer Cells vs Normal Cells</a> 

 

Boron Pathways for Cancer vs Normal cells
<table border="1" cellspacing="0" cellpadding="4">
<tr>
<th>Rank</th>
<th>Pathway / Axis</th>
<th>Cancer Cells</th>
<th>Normal Cells</th>
<th>Label</th>
<th>Primary Interpretation</th>
<th>Notes</th>
</tr>

<tr>
<td>1</td>
<td>Hormone / growth factor signaling (IGF-1, steroid modulation)</td>
<td>↓ growth-factor-driven proliferation</td>
<td>↔ optimized endocrine balance</td>
<td>Driver</td>
<td>Systemic growth signal modulation</td>
<td>Boron influences IGF-1, estrogen, and androgen signaling, indirectly reducing proliferative drive in hormone-responsive tumors</td>
</tr>

<tr>
<td>2</td>
<td>Inflammatory signaling (NF-κB / cytokines)</td>
<td>↓ pro-tumor inflammation</td>
<td>↓ inflammatory tone</td>
<td>Driver</td>
<td>Anti-inflammatory environment</td>
<td>Reduced chronic inflammation limits tumor-promoting microenvironmental signals</td>
</tr>

<tr>
<td>3</td>
<td>Cell membrane / signal transduction stability</td>
<td>↓ aberrant signaling responsiveness</td>
<td>↑ membrane and signaling stability</td>
<td>Secondary</td>
<td>Signal fidelity normalization</td>
<td>Boron supports membrane function and receptor signaling fidelity rather than directly inhibiting kinases</td>
</tr>

<tr>
<td>4</td>
<td>Mineral metabolism (Ca²⁺, Mg²⁺, vitamin D interaction)</td>
<td>↔ indirect growth restraint</td>
<td>↑ mineral homeostasis</td>
<td>Secondary</td>
<td>Metabolic support vs dysregulation buffering</td>
<td>Improved mineral balance supports normal cell resilience and systemic metabolic health</td>
</tr>

<tr>
<td>5</td>
<td>Reactive oxygen species (ROS)</td>
<td>↑ ROS (secondary, cancer-biased)</td>
<td>↔ or ↓ ROS (buffered)</td>
<td>Secondary</td>
<td>Metabolic-stress–linked oxidative pressure</td>
<td>ROS increase reflects impaired redox buffering and metabolic stress rather than direct redox chemistry</td>
</tr>

<tr>
<td>6</td>
<td>Glutathione (GSH) homeostasis</td>
<td>↓ GSH availability</td>
<td>↔ maintained</td>
<td>Secondary</td>
<td>Reduced antioxidant capacity</td>
<td>GSH depletion arises from impaired synthesis and NADPH support in cancer cells</td>
</tr>

<tr>
<td>7</td>
<td>Apoptosis</td>
<td>↔ minimal induction</td>
<td>↔ protected</td>
<td>Phenotypic</td>
<td>Non-cytotoxic profile</td>
<td>Boron does not act as a direct apoptotic trigger</td>
</tr>

</table>

<pre>
Distinct from compounds of main Redox Driver
| Compound | ROS ↑ mechanism | Category |
| ------------------- | --------------------------- | ------------------- |
| PEITC | Direct electrophilic stress | Redox driver |
| Selenium (selenite) | Redox cycling | Redox driver |
| Thymoquinone | Quinone cycling | Redox driver |
| **Boron** | Metabolic redox imbalance | **Secondary redox** |

</pre>

Research papers

Year	Title	Authors	PMID	Link
2025	Proteomic insights into the anti-cancer mechanisms of boron-based compounds in prostate cancer	Sevinc Yanar	—	https://www.sciencedirect.com/science/article/abs/pii/S2212429225007345
2025	Boron	NIH	—	https://ods.od.nih.gov/factsheets/Boron-HealthProfessional/?uid=1393ae0afe415s16
2025	Effects of Boron on Learning and Behavioral Disorders in Rat Autism Model Induced by Intracerebroventricular Propionic Acid	Nur Akman Alacabey	39397138	https://pubmed.ncbi.nlm.nih.gov/39397138/
2025	New and potential boron-containing compounds for treatment of Alzheimer's disease and cancers	Ferah Comert Onder	40600330	https://pubmed.ncbi.nlm.nih.gov/40600330/
2024	Boric Acid Affects the Expression of DNA Double-Strand Break Repair Factors in A549 Cells and A549 Cancer Stem Cells: An In Vitro Study	Tuğba Semerci Sevimli	PMC11442501	https://pmc.ncbi.nlm.nih.gov/articles/PMC11442501/
2024	The analysis of boric acid effect on epithelial-mesenchymal transition of CD133 + CD117 + lung cancer stem cells	Tuğba Semerci Sevimli	PMC11422429	https://pmc.ncbi.nlm.nih.gov/articles/PMC11422429/
2024	Evaluation of Boric Acid Treatment on microRNA-127-5p and Metastasis Genes Orchestration of Breast Cancer Stem Cells	Tuğba Semerci Sevimli	38963646	https://pubmed.ncbi.nlm.nih.gov/38963646/
2024	Borax induces ferroptosis of glioblastoma by targeting HSPA5/NRF2/GPx4/GSH pathways	Cengiz Tuncer	PMC10945083	https://pmc.ncbi.nlm.nih.gov/articles/PMC10945083/
2024	Protective Effect of Boric Acid Against Ochratoxin A-Induced Toxic Effects in Human Embryonal Kidney Cells (HEK293): A Study on Cytotoxic, Genotoxic, Oxidative, and Apoptotic Effects	Aşkın Tekin	PMC11750931	https://pmc.ncbi.nlm.nih.gov/articles/PMC11750931/
2024	Boron in wound healing: a comprehensive investigation of its diverse mechanisms	Nasrin Sedighi-Pirsaraei	PMC11557333	https://pmc.ncbi.nlm.nih.gov/articles/PMC11557333/
2024	The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats	Mustafa Cengiz	PMC11481652	https://pmc.ncbi.nlm.nih.gov/articles/PMC11481652/
2024	Boron Report	Dr. Gary Gonzalez	—	https://www.lifeextension.com/magazine/2003/11/report_boron
2024	Boric Acid and Borax Protect Human Lymphocytes from Oxidative Stress and Genotoxicity Induced by 3-Monochloropropane-1,2-diol	Hasan Turkez	PMC11442522	https://pmc.ncbi.nlm.nih.gov/articles/PMC11442522/
2024	In Vitro Effects of Boric Acid on Cell Cycle, Apoptosis, and miRNAs in Medullary Thyroid Cancer Cells	Onurcan Yıldırım	PMC11750916	https://pmc.ncbi.nlm.nih.gov/articles/PMC11750916/
2024	Boric Acid Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice	Xiaomin Zhang	—	https://link.springer.com/article/10.1007/s12011-024-04240-2
2024	Synthesis of DNA-Boron Cluster Composites and Assembly into Functional Nanoparticles with Dual, Anti-EGFR, and Anti-c-MYC Oncogene Silencing Activity	Dr. Katarzyna Bednarska-Szczepaniak,	—	https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202303531
2024	Boric Acid (Boron) Attenuates AOM-Induced Colorectal Cancer in Rats by Augmentation of Apoptotic and Antioxidant Mechanisms	Ahmed A J Jabbar	37770673	https://pubmed.ncbi.nlm.nih.gov/37770673/
2024	Borax affects cellular viability by inducing ER stress in hepatocellular carcinoma cells by targeting SLC12A5	Ceyhan Hacioglu	PMC11114215	https://pmc.ncbi.nlm.nih.gov/articles/PMC11114215/
2024	The Potential Role of Boron in the Modulation of Gut Microbiota Composition: An In Vivo Pilot Study	Nermin Basak Sentürk	PMC11510266	https://pmc.ncbi.nlm.nih.gov/articles/PMC11510266/
2024	Evaluation of Boric Acid Treatment on microRNA‐127‐5p and Metastasis Genes Orchestration of Breast Cancer Stem Cells	Tuğba Semerci Sevimli	—	https://link.springer.com/article/10.1007/s12011-024-04274-6
2023	Enhancement of ferroptosis by boric acid and its potential use as chemosensitizer in anticancer chemotherapy	Alessandro Corti	36468437	https://pubmed.ncbi.nlm.nih.gov/36468437/
2023	Therapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats with Experimental Alzheimer’s Disease	Çağrı Özdemir	PMC10200114	https://pmc.ncbi.nlm.nih.gov/articles/PMC10200114/
2023	Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells—An Issue Still Open	Giulia Paties Montagner	PMC10294879	https://pmc.ncbi.nlm.nih.gov/articles/PMC10294879/
2023	Boric Acid Alters the Expression of DNA Double Break Repair Genes in MCF-7-Derived Breast Cancer Stem Cells	Tuğba Semerci Sevimli	38087035	https://pubmed.ncbi.nlm.nih.gov/38087035/
2023	Borax regulates iron chaperone- and autophagy-mediated ferroptosis pathway in glioblastoma cells	Ceyhan Hacioglu	36988300	https://pubmed.ncbi.nlm.nih.gov/36988300/
2023	Boron Derivatives Inhibit the Proliferation of Breast Cancer Cells and Affect Tumor-Specific T Cell Activity In Vitro by Distinct Mechanisms	Eslam Essam Mohammed	36940038	https://pubmed.ncbi.nlm.nih.gov/36940038/
2023	Investigation of cytotoxic antiproliferative and antiapoptotic effects of nanosized boron phosphate filled sodium alginate composite on glioblastoma cancer cells	Fatma Sayan Poyraz	37934369	https://pubmed.ncbi.nlm.nih.gov/37934369/
2023	Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope	Mothana K Al-Omari	PMC10351539	https://pmc.ncbi.nlm.nih.gov/articles/PMC10351539/
2023	Does Boric Acid Inhibit Cell Proliferation on MCF-7 and MDA-MB-231 Cells in Monolayer and Spheroid Cultures by Using Apoptosis Pathways?	Dilek Bayram	37572183	https://pubmed.ncbi.nlm.nih.gov/37572183/
2023	Boric Acid Alleviates Gastric Ulcer by Regulating Oxidative Stress and Inflammation-Related Multiple Signaling Pathways	Ayşe Çakır Gündoğdu	37606879	https://pubmed.ncbi.nlm.nih.gov/37606879/
2023	Neuroprotective properties of borax against aluminum hydroxide-induced neurotoxicity: Possible role of Nrf-2/BDNF/AChE pathways in fish brain	Gonca Alak	—	https://www.sciencedirect.com/science/article/abs/pii/S0006899323000112
2023	Boric Acid Affects Cell Proliferation, Apoptosis, and Oxidative Stress in ALL Cells	Büşra Hilal	38015327	https://pubmed.ncbi.nlm.nih.gov/38015327/
2023	Boric Acid Exhibits Anticancer Properties in Human Endometrial Cancer Ishikawa Cells	Ayşe Çakır Gündoğdu	PMC10531031	https://pmc.ncbi.nlm.nih.gov/articles/PMC10531031/
2022	Boric acid exert anti-cancer effect in poorly differentiated hepatocellular carcinoma cells via inhibition of AKT signaling pathway	Erkan Kahraman	35868168	https://pubmed.ncbi.nlm.nih.gov/35868168/
2022	Cytotoxic and Apoptotic Effects of the Combination of Borax (Sodium Tetraborate) and 5-Fluorouracil on DLD-1 Human Colorectal Adenocarcinoma Cell Line	Ömer Faruk KIRLANGIÇ	PMC9438760	https://pmc.ncbi.nlm.nih.gov/articles/PMC9438760/
2022	Calcium fructoborate regulate colon cancer (Caco-2) cytotoxicity through modulation of apoptosis	Mehmet A Kisacam	35174920	https://pubmed.ncbi.nlm.nih.gov/35174920/
2022	Mineral requirements for mitochondrial function: A connection to redox balance and cellular differentiation	David W. Killilea	—	https://www.sciencedirect.com/science/article/pii/S0891584922000752
2022	The Boron Advantage: The Evolution and Diversification of Boron’s Applications in Medicinal Chemistry	Katia Messner	—	https://www.mdpi.com/1424-8247/15/3/264
2022	Effect of boron element on photoaging in rats	Seda Gul	—	https://www.sciencedirect.com/science/article/abs/pii/S1011134422000549
2022	Anti-cancer effect of boron derivatives on small-cell lung cancer	Emre Cebeci	35007916	https://pubmed.ncbi.nlm.nih.gov/35007916/
2022	Boric acid suppresses cell proliferation by TNF signaling pathway mediated apoptosis in SW-480 human colon cancer line	Murat Sevimli	35219976	https://pubmed.ncbi.nlm.nih.gov/35219976/
2021	Boron Level in the Prostate of the Normal Human: A Systematic Review	Prof. Dr. V. Zaichick	—	https://unisciencepub.com/wp-content/uploads/2021/04/Boron-Level-in-the-Prostate-of-the-Normal-Human-A-Systematic-Review.pdf
2021	Investigation of The Apoptotic and Antiproliferative Effects of Boron on CCL-233 Human Colon Cancer Cells	Şahabettin Can Özyarım	PMC8405086	https://pmc.ncbi.nlm.nih.gov/articles/PMC8405086/
2021	Boron Intake and decreased risk of mortality in kidney transplant recipients	Daan Kremer	PMC8854244	https://pmc.ncbi.nlm.nih.gov/articles/PMC8854244/
2021	Boric acid as a promising agent in the treatment of ovarian cancer: Molecular mechanisms	Umit Cabus	34175401	https://pubmed.ncbi.nlm.nih.gov/34175401/
2021	Polymers Based on Phenyl Boric Acid in Tumor-Targeted Therapy	Dexia Luo	33438559	https://pubmed.ncbi.nlm.nih.gov/33438559/
2021	Plasma boron concentrations in the general population: a cross-sectional analysis of cardio-metabolic and dietary correlates	Katharina S Weber	PMC8921125	https://pmc.ncbi.nlm.nih.gov/articles/PMC8921125/
2021	Boron Contents of German Mineral and Medicinal Waters and Their Bioavailability in Drosophila melanogaster and Humans	Ulrike Seidel	—	https://onlinelibrary.wiley.com/doi/full/10.1002/mnfr.202100345
2021	Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies	Hasan Turkez	34293392	https://pubmed.ncbi.nlm.nih.gov/34293392/
2020	Boron Chemistry for Medical Applications	Fayaz Ali	PMC7071021	https://pmc.ncbi.nlm.nih.gov/articles/PMC7071021/
2020	In vitro effects of boric acid on human liver hepatoma cell line (HepG2) at the half-maximal inhibitory concentration	Aysegul Tombuloglu	—	https://www.sciencedirect.com/science/article/abs/pii/S0946672X20301383
2020	The potential role of borophene as a radiosensitizer in boron neutron capture therapy (BNCT) and particle therapy (PT)	Pengyuan Qi	32342085	https://pubmed.ncbi.nlm.nih.gov/32342085/
2020	High Concentrations of Boric Acid Trigger Concentration-Dependent Oxidative Stress, Apoptotic Pathways and Morphological Alterations in DU-145 Human Prostate Cancer Cell Line	Ceyhan Hacioglu	31066018	https://pubmed.ncbi.nlm.nih.gov/31066018/
2020	Effects of Curcumin and Boric Acid Against Neurodegenerative Damage Induced by Amyloid Beta	Ceyhan Hacioglu	—	https://link.springer.com/article/10.1007/s12011-020-02511-2
2019	Boron inhibits apoptosis in hyperapoptosis condition: Acts by stabilizing the mitochondrial membrane and inhibiting matrix remodeling	Indusmita Routray	—	https://www.sciencedirect.com/science/article/abs/pii/S0304416518303209
2019	Boron's neurophysiological effects and tumoricidal activity on glioblastoma cells with implications for clinical treatment	Meric A Altinoz	30885023	https://pubmed.ncbi.nlm.nih.gov/30885023/
2019	Boron	Forrest H Nielsen	PMC7442337	https://pmc.ncbi.nlm.nih.gov/articles/PMC7442337/
2018	Using Boron Supplementation in Cancer Prevention and Treatment: A Review Article	Somayeh Nikkhah	—	https://www.researchgate.net/publication/352786926_Using_Boron_Supplementation_in_Cancer_Prevention_and_Treatment_A_Review_Article
2018	Discovery of boron-containing compounds as Aβ aggregation inhibitors and antioxidants for the treatment of Alzheimer's disease	Chuan-Jun Lu	—	https://pmc.ncbi.nlm.nih.gov/articles/PMC6254047/
2018	Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks	Haseeb Khaliq	29536335	https://pubmed.ncbi.nlm.nih.gov/29536335/
2018	Boric Acid Activation of eIF2α and Nrf2 Is PERK Dependent: a Mechanism that Explains How Boron Prevents DNA Damage and Enhances Antioxidant Status	Kristin E. Yamada	—	https://link.springer.com/article/10.1007/s12011-018-1498-4
2018	Boron and Inflammation	Jorge D. Flechas	—	https://restorativemedicine.org/wp-content/uploads/2018/09/FLechas.Boron-and-Inflammation.pdf
2018	The Effect of Boric Acid and Borax on Oxidative Stress, Inflammation, ER Stress and Apoptosis in Cisplatin Toxication and Nephrotoxicity Developing as a Result of Toxication	Ömer Hazman	29500724	https://pubmed.ncbi.nlm.nih.gov/29500724/
2018	Boric Acid Activation of eIF2α and Nrf2 Is PERK Dependent: a Mechanism that Explains How Boron Prevents DNA Damage and Enhances Antioxidant Statu	Kristin E Yamada	30196486	https://pubmed.ncbi.nlm.nih.gov/30196486/
2017	Boron Compounds in the Breast Cancer Cells Chemoprevention and Chemotherapy	Ion Romulus Scorei	—	https://ian-faulkner.com/wp-content/uploads/2017/08/boron-cancer-prevention-23268-2.pdf
2017	A new hope for obesity management: Boron inhibits adipogenesis in progenitor cells through the Wnt/β-catenin pathway	Ayşegül Doğan	—	https://www.sciencedirect.com/science/article/abs/pii/S0026049517300252
2017	Effect of Tumor Microenvironment on Selective Uptake of Boric Acid in HepG2 Human Hepatoma Cells	YU-CHI BAI	—	https://ar.iiarjournals.org/content/37/11/6347
2017	High concentrations of boric acid induce autophagy in cancer cell lines	Ruslan Al-Ali	—	https://www.biorxiv.org/content/10.1101/193441v1.full.pdf
2017	Boron-Based Inhibitors of the NLRP3 Inflammasome	Alex G. Baldwin	—	https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(17)30309-4
2017	In vitro and in vivo antitumour effects of phenylboronic acid against mouse mammary adenocarcinoma 4T1 and squamous carcinoma SCCVII cells	Maja Marasovic	PMC6010135	https://pmc.ncbi.nlm.nih.gov/articles/PMC6010135/
2016	Activation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake	Sarah E Kobylewski	PMC5344959	https://pmc.ncbi.nlm.nih.gov/articles/PMC5344959/
2016	A Study on the Anticarcinogenic Effects of Calcium Fructoborate	Burcu Erbaykent Tepedelen	28028787	https://pubmed.ncbi.nlm.nih.gov/28028787/
2015	Nothing Boring About Boron	Lara Pizzorno	PMC4712861	https://pmc.ncbi.nlm.nih.gov/articles/PMC4712861/
2014	Cytotoxic and apoptotic effects of boron compounds on leukemia cell line	Zerrin Canturk	PMC4698272	https://pmc.ncbi.nlm.nih.gov/articles/PMC4698272/
2014	Boric acid induces cytoplasmic stress granule formation, eIF2α phosphorylation, and ATF4 in prostate DU-145 cells	Kimberly A Henderson	PMC4300416	https://pmc.ncbi.nlm.nih.gov/articles/PMC4300416/
2012	Dietary Boron and Hormone Replacement Therapy as Risk Factors for Lung Cancer in Women	S Mahabir	PMC3390773	https://pmc.ncbi.nlm.nih.gov/articles/PMC3390773/
2012	Boron containing compounds as protease inhibitors	Reem Smoum	22519511	https://pubmed.ncbi.nlm.nih.gov/22519511/
2012	Sugar-borate esters--potential chemical agents in prostate cancer chemoprevention	Romulus Ion Scorei	23293883	https://pubmed.ncbi.nlm.nih.gov/23293883/
2011	Phenylboronic acid is a more potent inhibitor than boric acid of key signaling networks involved in cancer cell migration	Erin M McAuley	PMC3218604	https://pmc.ncbi.nlm.nih.gov/articles/PMC3218604/
2011	Prevalence of Prostate Cancer in High Boron-Exposed Population: A Community-Based Study	Talha Müezzinoğlu	—	https://www.researchgate.net/publication/50832657_Prevalence_of_Prostate_Cancer_in_High_Boron-Exposed_Population_A_Community-Based_Study
2011	Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines	Mohammad Reza Naghii	21129941	https://pubmed.ncbi.nlm.nih.gov/21129941/
2011	Growing Evidence for Human Health Benefits of Boron	Forrest H. Nielsen, PhD	—	https://journals.sagepub.com/doi/full/10.1177/2156587211407638
2010	Boric acid as a protector against paclitaxel genotoxicity	Hasan Turkez	20300661	https://pubmed.ncbi.nlm.nih.gov/20300661/
2010	Boron-containing phenoxyacetanilide derivatives as hypoxia-inducible factor (HIF)-1alpha inhibitors	Kazuki Shimizu	20083404	https://pubmed.ncbi.nlm.nih.gov/20083404/
2010	Boron-containing compounds as preventive and chemotherapeutic agents for cancer	Romulus I Scorei	19912103	https://pubmed.ncbi.nlm.nih.gov/19912103/
2009	Boron deprivation decreases liver S-adenosylmethionine and spermidine and increases plasma homocysteine and cysteine in rats	Forrest Harold Nielsen	19486830	https://pubmed.ncbi.nlm.nih.gov/19486830/
2009	Receptor Activated Ca2+ Release Is Inhibited by Boric Acid in Prostate Cancer Cells	Kimberly Henderson	PMC2698284	https://pmc.ncbi.nlm.nih.gov/articles/PMC2698284/
2009	Boric acid inhibits stored Ca2+ release in DU-145 prostate cancer cells	Wade T Barranco	18516691	https://pubmed.ncbi.nlm.nih.gov/18516691/
2009	Design, Synthesis, and Biological Activity of Boronic Acid-Based Histone Deacetylase Inhibitors	Nobuaki Suzuki	—	https://pubs.acs.org/doi/abs/10.1021/jm900125m
2008	Comparative effects of boric acid and calcium fructoborate on breast cancer cells	R Scorei	18176783	https://pubmed.ncbi.nlm.nih.gov/18176783/
2008	Dietary Boron and Hormone Replacement Therapy as Risk Factors for Lung Cancer in Women	S Mahabir	PMC3390773	https://pmc.ncbi.nlm.nih.gov/articles/PMC3390773/
2007	Boron intake and prostate cancer risk	Alejandro Gonzalez	17851770	https://pubmed.ncbi.nlm.nih.gov/17851770/
2007	Evaluation of ecological and in vitro effects of boron on prostate cancer risk (United States)	Wade T Barranco	17186423	https://pubmed.ncbi.nlm.nih.gov/17186423/
2007	Mechanism of boric acid cytotoxicity in breast cancer cell lines	Anu Elegbede	—	https://aacrjournals.org/cancerres/article/67/9_Supplement/3384/537484/Mechanism-of-boric-acid-cytotoxicity-in-breast
2007	https://aacrjournals.org/cancerres/article/67/9_Supplement/4220/535557/Boric-acid-induces-apoptosis-in-both-prostate-and	Stephen Carper	—	https://aacrjournals.org/cancerres/article/67/9_Supplement/4220/535557/Boric-acid-induces-apoptosis-in-both-prostate-and
2007	Effects of dietary boron on cervical cytopathology and on micronucleus frequency in exfoliated buccal cells	Mehmet Korkmaz	17295277	https://pubmed.ncbi.nlm.nih.gov/17295277/
2007	Boron as a Medicinal Ingredient in Oral Natural Health Products	Government of Canada	—	https://www.canada.ca/en/health-canada/services/drugs-health-products/reports-publications/natural-health-products/boron-medicinal-ingredient-oral-natural-health-products-natural-health-products-directorate-heath-canada-2007.html
2007	Boron and Prostate Cancer a Model for Understanding Boron Biology	Curtis Eckhert	—	https://link.springer.com/chapter/10.1007/978-1-4020-5382-5_28
2007	The Effect of Boron on the UPR in Prostate Cancer Cells is Biphasic	Kim Henderson	—	https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.21.5.a124-d
2006	Cellular changes in boric acid-treated DU-145 prostate cancer cells	W T Barranco	PMC3216419	https://pmc.ncbi.nlm.nih.gov/articles/PMC3216419/
2004	Boric acid inhibits human prostate cancer cell proliferation	Wade T Barranco	15500945	https://pubmed.ncbi.nlm.nih.gov/15500945/
2004	Dietary boron intake and prostate cancer risk	Yan Cui	15010890	https://pubmed.ncbi.nlm.nih.gov/15010890/
2004	Boron supplementation inhibits the growth and local expression of IGF-1 in human prostate adenocarcinoma (LNCaP) tumors in nude mice	Maria T Gallardo-Williams	14713551	https://pubmed.ncbi.nlm.nih.gov/14713551/
2004	EVIDENCE THAT BORON DOWN-REGULATES INFLAMMATION THROUGH THE NF-(KAPPA)B PATHWAY	DURICK, KATHY	—	https://www.ars.usda.gov/research/publications/publication/?seqNo115=171287
2003	Inhibition of the enzymatic activity of prostate-specific antigen by boric acid and 3-nitrophenyl boronic acid	Maria T Gallardo-Williams	12481254	https://pubmed.ncbi.nlm.nih.gov/12481254/
2003	Boron concentrations in selected foods from borate-producing regions in Turkey	Atilla Simsek	—	https://scijournals.onlinelibrary.wiley.com/doi/abs/10.1002/jsfa.1408
2001	Diadenosine phosphates and S-adenosylmethionine: novel boron binding biomolecules detected by capillary electrophoresis	N V Ralston	11420139	https://pubmed.ncbi.nlm.nih.gov/11420139/
1998	The nutritional and metabolic effects of boron in humans and animals	S Samman	10050922	https://pubmed.ncbi.nlm.nih.gov/10050922/
1994	Chemical disposition of boron in animals and humans	R F Moseman	PMC1566637	https://pmc.ncbi.nlm.nih.gov/articles/PMC1566637/

Year

Title

Authors

PMID

Link

Flag

2025

Proteomic insights into the anti-cancer mechanisms of boron-based compounds in prostate cancer

Sevinc Yanar

—

https://www.sciencedirect.com/science/article/abs/pii/S2212429225007345

2025

Boron

NIH

—

https://ods.od.nih.gov/factsheets/Boron-HealthProfessional/?uid=1393ae0afe415s16

2025

Effects of Boron on Learning and Behavioral Disorders in Rat Autism Model Induced by Intracerebroventricular Propionic Acid

Nur Akman Alacabey

39397138

https://pubmed.ncbi.nlm.nih.gov/39397138/

2025

New and potential boron-containing compounds for treatment of Alzheimer's disease and cancers

Ferah Comert Onder

40600330

https://pubmed.ncbi.nlm.nih.gov/40600330/

2024

Boric Acid Affects the Expression of DNA Double-Strand Break Repair Factors in A549 Cells and A549 Cancer Stem Cells: An In Vitro Study

Tuğba Semerci Sevimli

PMC11442501

https://pmc.ncbi.nlm.nih.gov/articles/PMC11442501/

2024

The analysis of boric acid effect on epithelial-mesenchymal transition of CD133 + CD117 + lung cancer stem cells

Tuğba Semerci Sevimli

PMC11422429

https://pmc.ncbi.nlm.nih.gov/articles/PMC11422429/

2024

Evaluation of Boric Acid Treatment on microRNA-127-5p and Metastasis Genes Orchestration of Breast Cancer Stem Cells

Tuğba Semerci Sevimli

38963646

https://pubmed.ncbi.nlm.nih.gov/38963646/

2024

Borax induces ferroptosis of glioblastoma by targeting HSPA5/NRF2/GPx4/GSH pathways

Cengiz Tuncer

PMC10945083

https://pmc.ncbi.nlm.nih.gov/articles/PMC10945083/

2024

Protective Effect of Boric Acid Against Ochratoxin A-Induced Toxic Effects in Human Embryonal Kidney Cells (HEK293): A Study on Cytotoxic, Genotoxic, Oxidative, and Apoptotic Effects

Aşkın Tekin

PMC11750931

https://pmc.ncbi.nlm.nih.gov/articles/PMC11750931/

2024

Boron in wound healing: a comprehensive investigation of its diverse mechanisms

Nasrin Sedighi-Pirsaraei

PMC11557333

https://pmc.ncbi.nlm.nih.gov/articles/PMC11557333/

2024

The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats

Mustafa Cengiz

PMC11481652

https://pmc.ncbi.nlm.nih.gov/articles/PMC11481652/

2024

Boron Report

Dr. Gary Gonzalez

—

https://www.lifeextension.com/magazine/2003/11/report_boron

2024

Boric Acid and Borax Protect Human Lymphocytes from Oxidative Stress and Genotoxicity Induced by 3-Monochloropropane-1,2-diol

Hasan Turkez

PMC11442522

https://pmc.ncbi.nlm.nih.gov/articles/PMC11442522/

2024

In Vitro Effects of Boric Acid on Cell Cycle, Apoptosis, and miRNAs in Medullary Thyroid Cancer Cells

Onurcan Yıldırım

PMC11750916

https://pmc.ncbi.nlm.nih.gov/articles/PMC11750916/

2024

Boric Acid Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice

Xiaomin Zhang

—

https://link.springer.com/article/10.1007/s12011-024-04240-2

2024

Synthesis of DNA-Boron Cluster Composites and Assembly into Functional Nanoparticles with Dual, Anti-EGFR, and Anti-c-MYC Oncogene Silencing Activity

Dr. Katarzyna Bednarska-Szczepaniak,

—

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202303531

2024

Boric Acid (Boron) Attenuates AOM-Induced Colorectal Cancer in Rats by Augmentation of Apoptotic and Antioxidant Mechanisms

Ahmed A J Jabbar

37770673

https://pubmed.ncbi.nlm.nih.gov/37770673/

2024

Borax affects cellular viability by inducing ER stress in hepatocellular carcinoma cells by targeting SLC12A5

Ceyhan Hacioglu

PMC11114215

https://pmc.ncbi.nlm.nih.gov/articles/PMC11114215/

2024

The Potential Role of Boron in the Modulation of Gut Microbiota Composition: An In Vivo Pilot Study

Nermin Basak Sentürk

PMC11510266

https://pmc.ncbi.nlm.nih.gov/articles/PMC11510266/

2024

Evaluation of Boric Acid Treatment on microRNA‐127‐5p and Metastasis Genes Orchestration of Breast Cancer Stem Cells

Tuğba Semerci Sevimli

—

https://link.springer.com/article/10.1007/s12011-024-04274-6

2023

Enhancement of ferroptosis by boric acid and its potential use as chemosensitizer in anticancer chemotherapy

Alessandro Corti

36468437

https://pubmed.ncbi.nlm.nih.gov/36468437/

2023

Therapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats with Experimental Alzheimer’s Disease

Çağrı Özdemir

PMC10200114

https://pmc.ncbi.nlm.nih.gov/articles/PMC10200114/

2023

Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells—An Issue Still Open

Giulia Paties Montagner

PMC10294879

https://pmc.ncbi.nlm.nih.gov/articles/PMC10294879/

2023

Boric Acid Alters the Expression of DNA Double Break Repair Genes in MCF-7-Derived Breast Cancer Stem Cells

Tuğba Semerci Sevimli

38087035

https://pubmed.ncbi.nlm.nih.gov/38087035/

2023

Borax regulates iron chaperone- and autophagy-mediated ferroptosis pathway in glioblastoma cells

Ceyhan Hacioglu

36988300

https://pubmed.ncbi.nlm.nih.gov/36988300/

2023

Boron Derivatives Inhibit the Proliferation of Breast Cancer Cells and Affect Tumor-Specific T Cell Activity In Vitro by Distinct Mechanisms

Eslam Essam Mohammed

36940038

https://pubmed.ncbi.nlm.nih.gov/36940038/

2023

Investigation of cytotoxic antiproliferative and antiapoptotic effects of nanosized boron phosphate filled sodium alginate composite on glioblastoma cancer cells

Fatma Sayan Poyraz

37934369

https://pubmed.ncbi.nlm.nih.gov/37934369/

2023

Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope

Mothana K Al-Omari

PMC10351539

https://pmc.ncbi.nlm.nih.gov/articles/PMC10351539/

2023

Does Boric Acid Inhibit Cell Proliferation on MCF-7 and MDA-MB-231 Cells in Monolayer and Spheroid Cultures by Using Apoptosis Pathways?

Dilek Bayram

37572183

https://pubmed.ncbi.nlm.nih.gov/37572183/

2023

Boric Acid Alleviates Gastric Ulcer by Regulating Oxidative Stress and Inflammation-Related Multiple Signaling Pathways

Ayşe Çakır Gündoğdu

37606879

https://pubmed.ncbi.nlm.nih.gov/37606879/

2023

Neuroprotective properties of borax against aluminum hydroxide-induced neurotoxicity: Possible role of Nrf-2/BDNF/AChE pathways in fish brain

Gonca Alak

—

https://www.sciencedirect.com/science/article/abs/pii/S0006899323000112

2023

Boric Acid Affects Cell Proliferation, Apoptosis, and Oxidative Stress in ALL Cells

Büşra Hilal

38015327

https://pubmed.ncbi.nlm.nih.gov/38015327/

2023

Boric Acid Exhibits Anticancer Properties in Human Endometrial Cancer Ishikawa Cells

Ayşe Çakır Gündoğdu

PMC10531031

https://pmc.ncbi.nlm.nih.gov/articles/PMC10531031/

2022

Boric acid exert anti-cancer effect in poorly differentiated hepatocellular carcinoma cells via inhibition of AKT signaling pathway

Erkan Kahraman

35868168

https://pubmed.ncbi.nlm.nih.gov/35868168/

2022

Cytotoxic and Apoptotic Effects of the Combination of Borax (Sodium Tetraborate) and 5-Fluorouracil on DLD-1 Human Colorectal Adenocarcinoma Cell Line

Ömer Faruk KIRLANGIÇ

PMC9438760

https://pmc.ncbi.nlm.nih.gov/articles/PMC9438760/

2022

Calcium fructoborate regulate colon cancer (Caco-2) cytotoxicity through modulation of apoptosis

Mehmet A Kisacam

35174920

https://pubmed.ncbi.nlm.nih.gov/35174920/

2022

Mineral requirements for mitochondrial function: A connection to redox balance and cellular differentiation

David W. Killilea

—

https://www.sciencedirect.com/science/article/pii/S0891584922000752

2022

The Boron Advantage: The Evolution and Diversification of Boron’s Applications in Medicinal Chemistry

Katia Messner

—

https://www.mdpi.com/1424-8247/15/3/264

2022

Effect of boron element on photoaging in rats

Seda Gul

—

https://www.sciencedirect.com/science/article/abs/pii/S1011134422000549

2022

Anti-cancer effect of boron derivatives on small-cell lung cancer

Emre Cebeci

35007916

https://pubmed.ncbi.nlm.nih.gov/35007916/

2022

Boric acid suppresses cell proliferation by TNF signaling pathway mediated apoptosis in SW-480 human colon cancer line

Murat Sevimli

35219976

https://pubmed.ncbi.nlm.nih.gov/35219976/

2021

Boron Level in the Prostate of the Normal Human: A Systematic Review

Prof. Dr. V. Zaichick

—

https://unisciencepub.com/wp-content/uploads/2021/04/Boron-Level-in-the-Prostate-of-the-Normal-Human-A-Systematic-Review.pdf

2021

Investigation of The Apoptotic and Antiproliferative Effects of Boron on CCL-233 Human Colon Cancer Cells

Şahabettin Can Özyarım

PMC8405086

https://pmc.ncbi.nlm.nih.gov/articles/PMC8405086/

2021

Boron Intake and decreased risk of mortality in kidney transplant recipients

Daan Kremer

PMC8854244

https://pmc.ncbi.nlm.nih.gov/articles/PMC8854244/

2021

Boric acid as a promising agent in the treatment of ovarian cancer: Molecular mechanisms

Umit Cabus

34175401

https://pubmed.ncbi.nlm.nih.gov/34175401/

2021

Polymers Based on Phenyl Boric Acid in Tumor-Targeted Therapy

Dexia Luo

33438559

https://pubmed.ncbi.nlm.nih.gov/33438559/

2021

Plasma boron concentrations in the general population: a cross-sectional analysis of cardio-metabolic and dietary correlates

Katharina S Weber

PMC8921125

https://pmc.ncbi.nlm.nih.gov/articles/PMC8921125/

2021

Boron Contents of German Mineral and Medicinal Waters and Their Bioavailability in Drosophila melanogaster and Humans

Ulrike Seidel

—

https://onlinelibrary.wiley.com/doi/full/10.1002/mnfr.202100345

2021

Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies

Hasan Turkez

34293392

https://pubmed.ncbi.nlm.nih.gov/34293392/

2020

Boron Chemistry for Medical Applications

Fayaz Ali

PMC7071021

https://pmc.ncbi.nlm.nih.gov/articles/PMC7071021/

2020

In vitro effects of boric acid on human liver hepatoma cell line (HepG2) at the half-maximal inhibitory concentration

Aysegul Tombuloglu

—

https://www.sciencedirect.com/science/article/abs/pii/S0946672X20301383

2020

The potential role of borophene as a radiosensitizer in boron neutron capture therapy (BNCT) and particle therapy (PT)

Pengyuan Qi

32342085

https://pubmed.ncbi.nlm.nih.gov/32342085/

2020

High Concentrations of Boric Acid Trigger Concentration-Dependent Oxidative Stress, Apoptotic Pathways and Morphological Alterations in DU-145 Human Prostate Cancer Cell Line

Ceyhan Hacioglu

31066018

https://pubmed.ncbi.nlm.nih.gov/31066018/

2020

Effects of Curcumin and Boric Acid Against Neurodegenerative Damage Induced by Amyloid Beta

Ceyhan Hacioglu

—

https://link.springer.com/article/10.1007/s12011-020-02511-2

2019

Boron inhibits apoptosis in hyperapoptosis condition: Acts by stabilizing the mitochondrial membrane and inhibiting matrix remodeling

Indusmita Routray

—

https://www.sciencedirect.com/science/article/abs/pii/S0304416518303209

2019

Boron's neurophysiological effects and tumoricidal activity on glioblastoma cells with implications for clinical treatment

Meric A Altinoz

30885023

https://pubmed.ncbi.nlm.nih.gov/30885023/

2019

Boron

Forrest H Nielsen

PMC7442337

https://pmc.ncbi.nlm.nih.gov/articles/PMC7442337/

2018

Using Boron Supplementation in Cancer Prevention and Treatment: A Review Article

Somayeh Nikkhah

—

https://www.researchgate.net/publication/352786926_Using_Boron_Supplementation_in_Cancer_Prevention_and_Treatment_A_Review_Article

2018

Discovery of boron-containing compounds as Aβ aggregation inhibitors and antioxidants for the treatment of Alzheimer's disease

Chuan-Jun Lu

—

https://pmc.ncbi.nlm.nih.gov/articles/PMC6254047/

2018

Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks

Haseeb Khaliq

29536335

https://pubmed.ncbi.nlm.nih.gov/29536335/

2018

Boric Acid Activation of eIF2α and Nrf2 Is PERK Dependent: a Mechanism that Explains How Boron Prevents DNA Damage and Enhances Antioxidant Status

Kristin E. Yamada

—

https://link.springer.com/article/10.1007/s12011-018-1498-4

2018

Boron and Inflammation

Jorge D. Flechas

—

https://restorativemedicine.org/wp-content/uploads/2018/09/FLechas.Boron-and-Inflammation.pdf

2018

The Effect of Boric Acid and Borax on Oxidative Stress, Inflammation, ER Stress and Apoptosis in Cisplatin Toxication and Nephrotoxicity Developing as a Result of Toxication

Ömer Hazman

29500724

https://pubmed.ncbi.nlm.nih.gov/29500724/

2018

Boric Acid Activation of eIF2α and Nrf2 Is PERK Dependent: a Mechanism that Explains How Boron Prevents DNA Damage and Enhances Antioxidant Statu

Kristin E Yamada

30196486

https://pubmed.ncbi.nlm.nih.gov/30196486/

2017

Boron Compounds in the Breast Cancer Cells Chemoprevention and Chemotherapy

Ion Romulus Scorei

—

https://ian-faulkner.com/wp-content/uploads/2017/08/boron-cancer-prevention-23268-2.pdf

2017

A new hope for obesity management: Boron inhibits adipogenesis in progenitor cells through the Wnt/β-catenin pathway

Ayşegül Doğan

—

https://www.sciencedirect.com/science/article/abs/pii/S0026049517300252

2017

Effect of Tumor Microenvironment on Selective Uptake of Boric Acid in HepG2 Human Hepatoma Cells

YU-CHI BAI

—

https://ar.iiarjournals.org/content/37/11/6347

2017

High concentrations of boric acid induce autophagy in cancer cell lines

Ruslan Al-Ali

—

https://www.biorxiv.org/content/10.1101/193441v1.full.pdf

2017

Boron-Based Inhibitors of the NLRP3 Inflammasome

Alex G. Baldwin

—

https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(17)30309-4

2017

In vitro and in vivo antitumour effects of phenylboronic acid against mouse mammary adenocarcinoma 4T1 and squamous carcinoma SCCVII cells

Maja Marasovic

PMC6010135

https://pmc.ncbi.nlm.nih.gov/articles/PMC6010135/

2016

Activation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake

Sarah E Kobylewski

PMC5344959

https://pmc.ncbi.nlm.nih.gov/articles/PMC5344959/

2016

A Study on the Anticarcinogenic Effects of Calcium Fructoborate

Burcu Erbaykent Tepedelen

28028787

https://pubmed.ncbi.nlm.nih.gov/28028787/

2015

Nothing Boring About Boron

Lara Pizzorno

PMC4712861

https://pmc.ncbi.nlm.nih.gov/articles/PMC4712861/

2014

Cytotoxic and apoptotic effects of boron compounds on leukemia cell line

Zerrin Canturk

PMC4698272

https://pmc.ncbi.nlm.nih.gov/articles/PMC4698272/

2014

Boric acid induces cytoplasmic stress granule formation, eIF2α phosphorylation, and ATF4 in prostate DU-145 cells

Kimberly A Henderson

PMC4300416

https://pmc.ncbi.nlm.nih.gov/articles/PMC4300416/

2012

Dietary Boron and Hormone Replacement Therapy as Risk Factors for Lung Cancer in Women

S Mahabir

PMC3390773

https://pmc.ncbi.nlm.nih.gov/articles/PMC3390773/

2012

Boron containing compounds as protease inhibitors

Reem Smoum

22519511

https://pubmed.ncbi.nlm.nih.gov/22519511/

2012

Sugar-borate esters--potential chemical agents in prostate cancer chemoprevention

Romulus Ion Scorei

23293883

https://pubmed.ncbi.nlm.nih.gov/23293883/

2011

Phenylboronic acid is a more potent inhibitor than boric acid of key signaling networks involved in cancer cell migration

Erin M McAuley

PMC3218604

https://pmc.ncbi.nlm.nih.gov/articles/PMC3218604/

2011

Prevalence of Prostate Cancer in High Boron-Exposed Population: A Community-Based Study

Talha Müezzinoğlu

—

https://www.researchgate.net/publication/50832657_Prevalence_of_Prostate_Cancer_in_High_Boron-Exposed_Population_A_Community-Based_Study

2011

Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines

Mohammad Reza Naghii

21129941

https://pubmed.ncbi.nlm.nih.gov/21129941/

2011

Growing Evidence for Human Health Benefits of Boron

Forrest H. Nielsen, PhD

—

https://journals.sagepub.com/doi/full/10.1177/2156587211407638

2010

Boric acid as a protector against paclitaxel genotoxicity

Hasan Turkez

20300661

https://pubmed.ncbi.nlm.nih.gov/20300661/

2010

Boron-containing phenoxyacetanilide derivatives as hypoxia-inducible factor (HIF)-1alpha inhibitors

Kazuki Shimizu

20083404

https://pubmed.ncbi.nlm.nih.gov/20083404/

2010

Boron-containing compounds as preventive and chemotherapeutic agents for cancer

Romulus I Scorei

19912103

https://pubmed.ncbi.nlm.nih.gov/19912103/

2009

Boron deprivation decreases liver S-adenosylmethionine and spermidine and increases plasma homocysteine and cysteine in rats

Forrest Harold Nielsen

19486830

https://pubmed.ncbi.nlm.nih.gov/19486830/

2009

Receptor Activated Ca2+ Release Is Inhibited by Boric Acid in Prostate Cancer Cells

Kimberly Henderson

PMC2698284

https://pmc.ncbi.nlm.nih.gov/articles/PMC2698284/

2009

Boric acid inhibits stored Ca2+ release in DU-145 prostate cancer cells

Wade T Barranco

18516691

https://pubmed.ncbi.nlm.nih.gov/18516691/

2009

Design, Synthesis, and Biological Activity of Boronic Acid-Based Histone Deacetylase Inhibitors

Nobuaki Suzuki

—

https://pubs.acs.org/doi/abs/10.1021/jm900125m

2008

Comparative effects of boric acid and calcium fructoborate on breast cancer cells

R Scorei

18176783

https://pubmed.ncbi.nlm.nih.gov/18176783/

2008

Dietary Boron and Hormone Replacement Therapy as Risk Factors for Lung Cancer in Women

S Mahabir

PMC3390773

https://pmc.ncbi.nlm.nih.gov/articles/PMC3390773/

2007

Boron intake and prostate cancer risk

Alejandro Gonzalez

17851770

https://pubmed.ncbi.nlm.nih.gov/17851770/

2007

Evaluation of ecological and in vitro effects of boron on prostate cancer risk (United States)

Wade T Barranco

17186423

https://pubmed.ncbi.nlm.nih.gov/17186423/

2007

Mechanism of boric acid cytotoxicity in breast cancer cell lines

Anu Elegbede

—

https://aacrjournals.org/cancerres/article/67/9_Supplement/3384/537484/Mechanism-of-boric-acid-cytotoxicity-in-breast

2007

https://aacrjournals.org/cancerres/article/67/9_Supplement/4220/535557/Boric-acid-induces-apoptosis-in-both-prostate-and

Stephen Carper

—

https://aacrjournals.org/cancerres/article/67/9_Supplement/4220/535557/Boric-acid-induces-apoptosis-in-both-prostate-and

2007

Effects of dietary boron on cervical cytopathology and on micronucleus frequency in exfoliated buccal cells

Mehmet Korkmaz

17295277

https://pubmed.ncbi.nlm.nih.gov/17295277/

2007

Boron as a Medicinal Ingredient in Oral Natural Health Products

Government of Canada

—

https://www.canada.ca/en/health-canada/services/drugs-health-products/reports-publications/natural-health-products/boron-medicinal-ingredient-oral-natural-health-products-natural-health-products-directorate-heath-canada-2007.html

2007

Boron and Prostate Cancer a Model for Understanding Boron Biology

Curtis Eckhert

—

https://link.springer.com/chapter/10.1007/978-1-4020-5382-5_28

2007

The Effect of Boron on the UPR in Prostate Cancer Cells is Biphasic

Kim Henderson

—

https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.21.5.a124-d

2006

Cellular changes in boric acid-treated DU-145 prostate cancer cells

W T Barranco

PMC3216419

https://pmc.ncbi.nlm.nih.gov/articles/PMC3216419/

2004

Boric acid inhibits human prostate cancer cell proliferation

Wade T Barranco

15500945

https://pubmed.ncbi.nlm.nih.gov/15500945/

2004

Dietary boron intake and prostate cancer risk

Yan Cui

15010890

https://pubmed.ncbi.nlm.nih.gov/15010890/

2004

Boron supplementation inhibits the growth and local expression of IGF-1 in human prostate adenocarcinoma (LNCaP) tumors in nude mice

Maria T Gallardo-Williams

14713551

https://pubmed.ncbi.nlm.nih.gov/14713551/

2004

EVIDENCE THAT BORON DOWN-REGULATES INFLAMMATION THROUGH THE NF-(KAPPA)B PATHWAY

DURICK, KATHY

—

https://www.ars.usda.gov/research/publications/publication/?seqNo115=171287

2003

Inhibition of the enzymatic activity of prostate-specific antigen by boric acid and 3-nitrophenyl boronic acid

Maria T Gallardo-Williams

12481254

https://pubmed.ncbi.nlm.nih.gov/12481254/

2003

Boron concentrations in selected foods from borate-producing regions in Turkey

Atilla Simsek

—

https://scijournals.onlinelibrary.wiley.com/doi/abs/10.1002/jsfa.1408

2001

Diadenosine phosphates and S-adenosylmethionine: novel boron binding biomolecules detected by capillary electrophoresis

N V Ralston

11420139

https://pubmed.ncbi.nlm.nih.gov/11420139/

1998

The nutritional and metabolic effects of boron in humans and animals

S Samman

10050922

https://pubmed.ncbi.nlm.nih.gov/10050922/

1994

Chemical disposition of boron in animals and humans

R F Moseman

PMC1566637

https://pmc.ncbi.nlm.nih.gov/articles/PMC1566637/

tbResList Print — Bor Boron

Product

Pathway results for Effect on Cancer / Diseased Cells

Redox & Oxidative Stress ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Protein Aggregation ⓘ

Hormonal & Nuclear Receptors ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Pathway results for Effect on Normal Cells

Redox & Oxidative Stress ⓘ

Metal & Cofactor Biology ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

DNA Damage & Repair ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Synaptic & Neurotransmission ⓘ

Protein Aggregation ⓘ

Hormonal & Nuclear Receptors ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Research papers