Description: <p><b>Morin</b> - 2',3,4',5,7-Pentahydroxyflavone</p>
<p><b>Recommended Abbreviation:</b> MOR</p>
<p><b>Type:</b> Flavonol / polyphenolic flavonoid</p>
<p><b>Sources:</b> Morin occurs naturally in several plants and foods, including members of Morus, Maclura, Artocarpus, and Psidium species.</p>
<p><b>Function:</b> Morin is a polyphenolic flavonol with antioxidant, anti-inflammatory, metabolic, neuroprotective, and antiproliferative activities. It modulates oxidative stress, mitochondrial function, inflammatory signaling, apoptosis, cell-cycle regulation, and signaling pathways including NF-κB, STAT3, PI3K/AKT, MAPK, and GSK-3β.</p>
<p><b>Cancer:</b> Preclinical studies show broad anticancer activity. Morin can inhibit proliferation, migration, invasion, epithelial-mesenchymal transition, inflammatory signaling, and angiogenic pathways while promoting apoptosis and cell-cycle arrest. Reported molecular pathways include STAT3, NF-κB, PI3K/AKT, MAPK, Hippo, MMPs, and ROS-related signaling. Human anticancer efficacy has not been established.</p>
<p><b>Alzheimer's Disease:</b> Preclinical evidence suggests neuroprotective activity. Morin can reduce amyloid-β-induced oxidative stress, mitochondrial dysfunction, calcium dysregulation, and neuronal injury and may inhibit GSK-3β-related signaling relevant to tau hyperphosphorylation and amyloid pathology. Evidence remains experimental, with no established clinical efficacy for Alzheimer's disease.</p>