tbResList Print — VT Vitexin

Filters: qv=462, qv2=%, rfv=%

Product

VT Vitexin
Description: <p><b>Vitexin</b> - Apigenin-8-C-Glucoside</p>

<p><b>Alternative Names:</b> Apigenin-8-C-glucoside, apigenin-8-C-β-D-glucopyranoside</p>

<p><b>Type:</b> Flavone C-glycoside / apigenin derivative</p>

<p><b>Function:</b> Vitexin is a naturally occurring C-glycosylated flavone in which glucose is attached to apigenin at the C-8 position. It exhibits antioxidant, anti-inflammatory, metabolic, cardiovascular, neuroprotective, and antiproliferative activities and can modulate pathways involving NF-κB, Nrf2/HO-1, MAPK, PI3K/AKT, AMPK, HIF-1α, apoptosis, and oxidative stress.</p>

-see also <a href="https://nestronics.ca/dbx/tbResList.php?qv=463">IsoVitexin</a>

<p><b>Cancer:</b> Preclinical studies indicate antiproliferative, pro-apoptotic, anti-migratory, anti-invasive, and anti-inflammatory effects across multiple cancer models. Reported mechanisms include modulation of PI3K/AKT, MAPK, NF-κB, HIF-1α, ROS, apoptosis, and cell-cycle signaling. Clinical anticancer efficacy has not been established.</p>

<p><b>Alzheimer's Disease:</b> Preclinical evidence suggests neuroprotective activity through antioxidant and anti-inflammatory effects, reduction of neuronal injury, regulation of oxidative stress and mitochondrial function, and modulation of signaling pathways relevant to cognitive impairment and amyloid-associated neurotoxicity. Clinical efficacy for Alzheimer's disease has not been established.</p>

Pathway results for Effect on Cancer / Diseased Cells

NA, unassigned(tgid=0) ⓘ

ACE/ACE1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   MDA↑, 1,   SOD↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ABL1↓, 1,   BCR↓, 1,   MMP↓, 4,   mtDam↑, 1,   Raf↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   LDH↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   Akt↑, 1,   p‑Akt↓, 1,   Apoptosis↑, 6,   BAX↑, 1,   BAX↓, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   Casp3↑, 5,   cl‑Casp3↑, 1,   Casp9↑, 3,   Cyt‑c↑, 1,   p‑JNK↑, 1,   MAPK↓, 1,   p38↑, 1,   PUMA↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP90↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3II↓, 1,   SESN2↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs?, 1,   EMT↓, 1,   ERK↓, 1,   p‑ERK↓, 1,   FOXO3↓, 1,   HRAS↓, 1,   Let-7↓, 1,   miR-34a↑, 1,   mTOR↓, 2,   p‑mTOR↓, 1,   NRAS↓, 1,   PI3K↓, 3,   PI3K↑, 1,   p‑PI3K↓, 2,   TumCG?, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   KRAS↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   TumMeta↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 4,   miR-17↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↓, 2,   NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↝, 2,   eff↑, 1,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

KRAS↓, 1,   LDH↑, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoPv↑, 2,   toxicity↓, 1,  
Total Targets: 77

Pathway results for Effect on Normal Cells

NA, unassigned(tgid=0) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   GDNF↑, 1,   GFAP↓, 1,   H+/K+-ATPase↓, 1,   IRes↝, 1,   Learn↑, 1,   NeuroI↓, 1,   ONOO↓, 1,   Stroke↓, 4,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   Ferroptosis↓, 1,   GPx↑, 1,   GPx4↑, 1,   GSH↑, 2,   GSTs↑, 1,   HO-1↑, 3,   hyperG↓, 1,   lipid-P↓, 2,   MDA↓, 2,   MFN2↑, 1,   MPO↓, 1,   NQO1↑, 1,   NRF2↑, 4,   ROS↓, 6,   SOD↑, 2,   TAC↑, 1,   TOS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   DRP1/DNM1L↓, 1,   MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   GlucoseCon↑, 1,   LDH↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 1,   ATF2↑, 1,   Casp3↓, 1,   Ferroptosis↓, 1,   iNOS↓, 1,   MAPK↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   GRP78/BiP↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FOXO3↑, 1,   GSK‐3β↑, 1,   HH↓, 1,   mTOR↓, 1,   PI3K↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   PTP1B↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT4↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL1β↓, 1,   IL33↓, 1,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 6,   NF-kB↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 6,   BChE↓, 3,   BDNF↑, 1,   ChE↓, 1,   PSD95↑, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,   BACE/β-secretase↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↝, 1,   BioAv↑, 1,   Dose↓, 1,   Dose↝, 3,   eff↑, 1,   eff↝, 1,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 1,   IL6↓, 1,   LDH↓, 2,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 2,   AntiDiabetic↑, 2,   AntiTum↑, 1,   cardioP↑, 2,   chemoP↑, 1,   cognitive↓, 1,   hepatoP↑, 2,   memory↑, 3,   motorD↑, 1,   neuroP↑, 5,   Obesity↓, 2,   OS↑, 1,   RenoP↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 97

Research papers

Year Title Authors PMID Link Flag
2015Flavonoid analysis of buckwheat sproutsTae-Gyu Nam25306322pubmed.ncbi.nlm.nih.gov/25306322/0
2008Comparison of phenolic compositions between common and tartary buckwheat (Fagopyrum) sproutsSun-Ju Kim26047265https://pubmed.ncbi.nlm.nih.gov/26047265/0
2023Vitexin and isovitexin delayed ageing and enhanced stress-resistance through the activation of the SKN-1/Nrf2 signaling pathwayMingfang Tao37604809https://pubmed.ncbi.nlm.nih.gov/37604809/0
2017Molecular targets of vitexin and isovitexin in cancer therapy: a critical reviewKumar Ganesan28891090https://pubmed.ncbi.nlm.nih.gov/28891090/0
2017Plasma Pharmacokinetics, Bioavailability, and Tissue Distribution of Four C-Glycosyl Flavones from Mung Bean (Vigna radiata L.) Seed Extracts in Rat by Ultrahigh-Performance Liquid Chromatography-Tandem Mass SpectrometryYan Bai28627167https://pubmed.ncbi.nlm.nih.gov/28627167/0
2014Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigeninJae Sue Choi24291393https://pubmed.ncbi.nlm.nih.gov/24291393/0
2021Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A ReviewHui Xu34551518https://pubmed.ncbi.nlm.nih.gov/34551518/0
2026Vitexin Protects Against Scopolamine-Induced Cognitive Impairment by Preserving Synaptic Integrity and Modulating Nrf2/HO-1 and NF-κB Signaling PathwaysCaner YildirimPMC13303689https://pmc.ncbi.nlm.nih.gov/articles/PMC13303689/0
2025Dietary Flavonoids Vitexin and Isovitexin: New Insights into Their Functional Roles in Human Health and Disease PreventionWeiqi YanPMC12296012https://pmc.ncbi.nlm.nih.gov/articles/PMC12296012/0
2025Vitexin's Role in Colon Cancer Apoptosis: AMPK/mTOR Pathway Modulation Explored Through Experimental and Computational ApproachesMohammed Abdalla Hussein40129142https://pubmed.ncbi.nlm.nih.gov/40129142/0
2025Vitexin induces apoptosis and enhances daunorubicin efficacy in acute leukemia via modulation of the HIF-1α/Bcl-2/caspase-3 pathwayChutiphong JirawatpraphakornPMC12827246https://pmc.ncbi.nlm.nih.gov/articles/PMC12827246/0
2022Vitexin Induces Apoptosis in MCF-7 Breast Cancer Cells through the Regulation of Specific miRNAs ExpressionReza NajafipourPMC10440000https://pmc.ncbi.nlm.nih.gov/articles/PMC10440000/0
2022Vitexin isolated from Prosopis cineraria leaves induce apoptosis in K-562 leukemia cells via inhibition of the BCR-ABL-Ras-Raf pathwayMonaj Kumar Sarkar34109977https://pubmed.ncbi.nlm.nih.gov/34109977/0
2021Vitexin Inhibits Gastric Cancer Growth and Metastasis through HMGB1-mediated Inactivation of the PI3K/AKT/mTOR/HIF-1α Signaling PathwayPeng ZhouPMC8753280https://pmc.ncbi.nlm.nih.gov/articles/PMC8753280/0
2020Review of the effects of vitexin in oxidative stress-related diseasesFatemeh BabaeiPMC7300089https://pmc.ncbi.nlm.nih.gov/articles/PMC7300089/0
2019Vitexin induces apoptosis through mitochondrial pathway and PI3K/Akt/mTOR signaling in human non-small cell lung cancer A549 cellsXiaoli LiuPMC6387544https://pmc.ncbi.nlm.nih.gov/articles/PMC6387544/0
2018A Brief Review on the Neuroprotective Mechanisms of VitexinLayana Karine F LimaPMC6304565https://pmc.ncbi.nlm.nih.gov/articles/PMC6304565/0
2016Vitexin suppresses autophagy to induce apoptosis in hepatocellular carcinoma via activation of the JNK signaling pathwayJin-Dan HePMC5356678https://pmc.ncbi.nlm.nih.gov/articles/PMC5356678/0
2012Apoptosis triggered by vitexin in U937 human leukemia cells via a mitochondrial signaling pathwayChao-Ying Lee22941432https://pubmed.ncbi.nlm.nih.gov/22941432/0