Description: <p><b>Acer okamotoanum</b> - Acer okamotoanum Extract</p>
<p><b>Alternative Names:</b> Acer okamotoanum, Ulleungdo maple</p>
<p><b>Type:</b> Botanical extract / flavonoid-rich plant product</p>
<p><b>Source:</b> Acer okamotoanum is a maple species native to Korea, particularly Ulleung Island. Experimental studies have used leaf extracts and solvent fractions, including flavonoid-rich ethyl acetate fractions.</p>
<p><b>Active Constituents:</b> Reported constituents include isoquercitrin, quercitrin, afzelin, and other phenolic and flavonoid compounds.</p>
<p><b>Function:</b> Acer okamotoanum extracts exhibit antioxidant, anti-inflammatory, cytoprotective, and neuroprotective activities. Experimental studies show reductions in reactive oxygen species, lipid peroxidation, inflammatory signaling, and apoptotic damage, together with preservation of neuronal viability and cellular stress resistance.</p>
<p><b>Alzheimer's Disease:</b> Preclinical evidence suggests potential neuroprotective and cognition-preserving effects. Acer okamotoanum extract has improved learning and memory and reduced oxidative stress in experimental models involving amyloid-β and metabolic stress. Constituents including isoquercitrin, quercitrin, and afzelin may contribute to these effects through antioxidant, anti-inflammatory, and amyloid-related mechanisms. Clinical efficacy for Alzheimer's disease has not been established.</p>