Description: <p><b>Annona atemoya Leaf Extract</b> - Atemoya Leaf Extract</p>
<p><b>Alternative Names:</b> Annona atemoya leaf extract, Atemoya leaf extract, AAL extract</p>
<p><b>Type:</b> Botanical extract / polyphenol- and flavonoid-containing plant product</p>
<p><b>Source:</b> Leaves of Annona atemoya, a hybrid of Annona squamosa and Annona cherimola.</p>
<p><b>Active Constituents:</b> Reported constituents include <b>rutin, isoquercitrin</b>, other flavonoids, phenolic compounds, proanthocyanidins, and alkaloids. Rutin was the most abundant quantified compound in one Alzheimer’s disease-focused ethanol extract study, and both rutin and isoquercitrin inhibited amyloid-β aggregation.</p>
<p><b>Function:</b> Annona atemoya leaf extract exhibits antioxidant, neuroprotective, anti-inflammatory, cholinergic, and antiproliferative activities in experimental models. Reported effects include reduction of reactive oxygen species and neuronal cell death, modulation of EGFR/GRK2 and Akt/CREB/BDNF signaling, and protection of cognitive function.</p>
<p><b>Cancer:</b> Preclinical leaf-extract studies show antiproliferative activity against cancer cell lines including HeLa cervical cancer and HepG2 hepatocellular carcinoma cells. Activity has been associated particularly with alkaloid-containing fractions. Direct clinical anticancer efficacy has not been established.</p>
<p><b>Alzheimer's Disease:</b> Preclinical evidence is relatively strong for a botanical extract. Annona atemoya leaf extract inhibits amyloid-β aggregation, reduces oxidative stress and neuronal cell death, and improves learning and memory in Aβ-induced Alzheimer's disease-like mouse models. Reported mechanisms include modulation of EGFR/GRK2 signaling and preservation of neuronal and neurotrophic signaling. It also improves cognitive impairment in scopolamine-treated mice through effects on cholinergic function, oxidative stress, Akt, CREB, and BDNF. Human clinical efficacy has not been established.</p>