Description: <p><b>Tanshinone I</b></p>
<p><b>Recommended Abbreviation:</b> Tan I</p>
<p><b>Type:</b> Natural product / diterpene quinone / tanshinone</p>
<p><b>Source:</b> Lipophilic bioactive constituent isolated primarily from the roots and rhizomes of <i>Salvia miltiorrhiza</i> Bunge (Danshen).</p>
<p><b>Function:</b> Tanshinone I exhibits anticancer, anti-inflammatory, antioxidant, and other pharmacological activities. It can modulate signaling pathways involved in proliferation, apoptosis, cell-cycle regulation, migration, invasion, angiogenesis, and cellular stress responses.</p>
<p><b>Cancer:</b> Tanshinone I has demonstrated broad preclinical anticancer activity, including proliferation ↓, migration/invasion ↓, angiogenesis ↓, apoptosis ↑, and modulation of PI3K/AKT, MAPK, STAT3, and other tumor-associated signaling pathways. Its effects vary with cancer type and experimental conditions.</p>